Investigating a new treatment for pain caused by chemotherapy
Anti-nociceptive actions of CART II in chemotherapy-induced peripheral neuropathy
This study is looking at a new treatment called CART II to help relieve the painful nerve issues that some cancer patients experience after chemotherapy, and it aims to find a safer way to manage that pain for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Polytechnic Inst and St Univ NIH-funded |
| Lab location | 1 site (Blacksburg, United States) |
| Project ID | NIH-11088839 on NIH RePORTER |
What this research studies
This research focuses on finding a novel non-opioid treatment for chemotherapy-induced peripheral neuropathy (CIPN), a painful condition affecting many cancer patients. The study explores the effects of a neuropeptide called CART II, which has shown promise in reversing pain-like behaviors in animal models. By understanding how CART II interacts with specific receptors in the brain, researchers aim to develop a safer and more effective pain management option for patients suffering from CIPN. The research will involve comprehensive evaluations of CART II's effects on pain in both male and female subjects.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients experiencing chemotherapy-induced peripheral neuropathy.
Not a fit: Patients who are not undergoing chemotherapy or do not experience neuropathic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a new, safer treatment option for managing pain in cancer patients undergoing chemotherapy.
How similar studies have performed: Previous studies have shown promise in using neuropeptides for pain management, but this specific approach with CART II is novel and untested in humans.
Where this research is happening
Blacksburg, United States
- Virginia Polytechnic Inst and St Univ — Blacksburg, United States (Active)
Researchers
- Principal investigator: Buczynski, Matthew Wallace — Virginia Polytechnic Inst and St Univ
- Study coordinator: Buczynski, Matthew Wallace
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.