Understanding how aging cells contribute to nerve pain after chemotherapy
Senescent stromal cells drive chemotherapy-induced peripheral neuropathy
This study is looking at how certain aging cells in the body might cause the painful nerve problems that some cancer survivors experience after chemotherapy, with the hope of finding new ways to help manage or prevent these symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11108403 on NIH RePORTER |
What this research studies
This research investigates the role of senescent stromal cells in causing chemotherapy-induced peripheral neuropathy (CIPN), a painful condition affecting many cancer survivors. By studying how these aging cells impact nerve function and repair, the research aims to identify potential therapeutic targets to alleviate symptoms. The approach includes genetic mouse models and laboratory assays to explore the mechanisms behind nerve damage and the role of specific cellular factors. Patients may benefit from insights that could lead to new treatments for managing or preventing CIPN.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer survivors who have experienced nerve pain or discomfort following chemotherapy treatment.
Not a fit: Patients who have not undergone chemotherapy or do not experience peripheral neuropathy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce or prevent nerve pain in cancer survivors after chemotherapy.
How similar studies have performed: Previous research has shown promising results in understanding the role of cellular senescence in various conditions, suggesting that this approach may yield valuable insights into CIPN.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Stewart, Sheila a — Washington University
- Study coordinator: Stewart, Sheila a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.