Condition

Cardiomyopathy clinical trials and research

• 21Clinical trials
• 252NIH research projects
• 16Countries

Newest Cardiomyopathy clinical trials

All recruiting trials (21)

• ATR 1072 in PRKAG2 Syndrome

  A first-in-human study tests ATR 1072 to see if it is safe and how it behaves in adults with PRKAG2 Syndrome.

  Recruiting Phase 1/2 Atrium Therapeutics · Kansas City, Missouri · NCT07738107

• Modeling heart failure in Duchenne and Becker muscular dystrophy to find surrogate heart measures

  This study will look at heart disease in people with Duchenne/Becker muscular dystrophy and carriers to see if MRI-based heart measures can predict death or major heart problems.

  Recruiting at 9 sites Vanderbilt University Medical Center · Sacramento, California and 8 other locations · NCT07674758

• Multimodal Cardiac MRI to See How the Heart Is Working

  This study tests a comprehensive MRI approach to characterize heart structure and tissue in adults with suspected or confirmed cardiovascular disease.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07617844

• Genetic testing for AF-triggered cardiomyopathy

  We will test whether people who develop heart failure during atrial fibrillation carry specific disease-causing gene variants compared with people who have AF but do not weaken their heart.

  Recruiting Barts & The London NHS Trust · London · NCT07574697

• Mavacamten use and effectiveness in adults with obstructive hypertrophic cardiomyopathy in Japan

  This project will see how well mavacamten works and how safe it is for adults in Japan with symptomatic obstructive hypertrophic cardiomyopathy who are receiving cibenzoline.

  Recruiting Bristol-Myers Squibb · Minato-ku, Tokyo · NCT07541833

• DMD gene changes and heart function in boys and young men with dystrophinopathies

  This study will test whether specific DMD gene changes and routine heart tests (blood biomarkers, ECG, and echocardiography) can help identify early heart problems in boys and young men aged 2–24 with genetically confirmed dystrophinopathies.

  Recruiting Aristotle University Of Thessaloniki · Thessaloniki · NCT07515235

• Deep learning to analyze and track echocardiograms

  This project will test AI tools that help clinicians read echocardiograms and flag adults who may have genetic cardiomyopathy, ischemic heart disease, or cardiac amyloidosis to see if interpretation improves and diagnoses happen faster.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07308704

• Community- or home-based exercise for adults with weakened heart or lungs

  This test will see if an eight-week, community- or home-based exercise program can improve heart and lung function in adults 18–85 with reduced cardiopulmonary fitness.

  Recruiting Guangdong Provincial People's Hospital · Guangzhou, Guangdong · NCT07154355

• Arrhythmia mapping with a paddle-shaped multi-electrode catheter

  This test uses a new high-density multi-electrode catheter to see if it can safely map atrial and ventricular arrhythmias in adults having catheter mapping and ablation.

  Recruiting at 5 sites Biosense Webster, Inc. · Bruges and 4 other locations · NCT07116525

• Carvedilol versus metoprolol succinate in people with heart failure and an implanted defibrillator

  This study will test whether switching from metoprolol succinate to carvedilol reduces ICD therapies, heart-related hospitalizations, or cardiovascular death in adults with HFrEF and an ICD.

  Recruiting at 13 sites Phase 4 University of Rochester · Scottsdale, Arizona and 12 other locations · NCT06964464

• Collecting clinical and genomic data to diagnose rare inherited cardiomyopathy

  This study is trying to collect health information and genetic data from people with cardiomyopathy to better understand and diagnose this heart condition, especially when regular tests don’t give clear results.

  Recruiting Yonsei University · Seoul · NCT06948344

• Using AI to enhance cardiology patient care

  This study is testing if using AI tools can help cardiologists make better decisions when treating patients with heart conditions compared to traditional methods.

  Recruiting Stanford University · Palo Alto, California · NCT06935253

• Understanding the genetics of arrhythmia-induced cardiomyopathy

  This study is trying to see if certain genetic traits in people with arrhythmia-induced cardiomyopathy can help predict their heart health and outcomes after treatment.

  Recruiting at 2 sites Hospital Universitario 12 de Octubre · Ciudad Real, Castille-La Mancha and 3 other locations · NCT06896266

• Observational study of patients with systemic amyloidosis

  This study looks at patients with systemic amyloidosis, especially those with heart issues, to learn more about their experiences and outcomes.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT06866912

• Clinical course of cardiomyopathy in people with Friedreich ataxia

  This study follows people with Friedreich ataxia who have cardiomyopathy to see how their heart disease changes over time and to identify who may later be eligible for a gene therapy study.

  Recruiting at 18 sites Lexeo Therapeutics · La Jolla, California and 18 other locations · NCT06865482

• Evaluating heart recovery with Impella 5.5 in severe heart failure patients

  This study is testing how well the Impella 5.5 heart device helps people with severe heart failure recover after a heart attack.

  Recruiting Columbia University · New York, New York · NCT06800716

• Understanding Arrhythmia-induced Cardiomyopathy

  This study is trying to learn more about how common arrhythmia-induced heart problems are in patients with weakened heart function and what factors might lead to worse outcomes or hospital visits.

  Recruiting University Hospital, Basel, Switzerland · Basel · NCT05662293

• Understanding TRPC6 to Prevent Heart Issues in Breast Cancer Patients Receiving Chemotherapy

  This study is trying to see if looking at a specific gene can help prevent heart problems in breast cancer patients who are getting chemotherapy.

  Recruiting at 2 sites Mayo Clinic · Gainesville, Florida and 1 other locations · NCT05507879

• Imaging cardiac amyloid deposits in patients with primary amyloidosis

  This study is testing new imaging techniques to see how amyloid deposits affect heart health in people with primary light chain amyloidosis.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT02641145

• Characterizing patients with rare cardiovascular diseases

  This study is trying to learn more about rare heart diseases by testing people who have these conditions, their family members, and healthy volunteers to see how these diseases develop and what causes them.

  Recruiting at 2 sites National Institutes of Health Clinical Center (CC) · Washington D.C., District of Columbia and 2 other locations · NCT01143454

• Exploring the genetics behind heart and muscle diseases

  This study is trying to find out how genetics play a role in heart and muscle diseases by looking at blood samples from families with these conditions.

  Recruiting University of Chicago · Chicago, Illinois · NCT00138931

NIH-funded research (newest 40 of 252)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Global bromocriptine trial for postpartum cardiomyopathy

  A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with peripartum cardiomyopathy.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11625554

• Global Bromocriptine Add-on for Postpartum Heart Failure (GLOBal PPCM)

  A large international study will test whether adding the dopamine agonist bromocriptine to standard heart failure care helps postpartum women with a specific heart condition.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11625553

• Global Bromocriptine Trial for Postpartum Heart Failure (GLOBal PPCM)

  A large international study will test whether adding bromocriptine to standard heart-failure care helps women with postpartum cardiomyopathy.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11625552

• Bromocriptine as add-on therapy for postpartum cardiomyopathy across multiple sites

  A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with postpartum cardiomyopathy.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11625551

• Global bromocriptine trial to help postpartum heart failure patients

  A large international trial tests whether adding bromocriptine to standard heart failure treatment improves outcomes for new mothers with a specific pregnancy-related heart condition.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11625550

• Global Bromocriptine Trial to Help Postpartum Heart Failure

  A large international study will test whether adding bromocriptine to standard heart failure treatment helps women with postpartum cardiomyopathy.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11625549

• Bromocriptine Added to Standard Care for Postpartum Heart Muscle Disease (GLOBal PPCM)

  A large international study will test whether adding the drug bromocriptine to standard heart failure treatment helps women with postpartum cardiomyopathy.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11625548

• Global bromocriptine trial for postpartum heart muscle disease

  A large international study will test whether adding bromocriptine to standard heart-failure treatment helps women with peripartum cardiomyopathy after delivery.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11625547

• Global bromocriptine trial for postpartum heart failure (PPCM)

  A large international trial will test whether adding bromocriptine to standard heart failure treatment helps women with peripartum cardiomyopathy after giving birth.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11625546

• Bromocriptine addition for postpartum cardiomyopathy in a global trial

  A large international study will test whether adding bromocriptine to standard heart failure therapy helps women after childbirth who have PPCM.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11625544

• Global Bromocriptine Trial for Postpartum Heart Disease (PPCM)

  A large international trial will test whether adding bromocriptine to standard heart-failure treatment improves outcomes for women with postpartum cardiomyopathy.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11625543

• Global Bromocriptine Trial for Postpartum Heart Failure (GLOBal PPCM)

  This study tests whether adding bromocriptine to standard heart failure treatment helps women with peripartum cardiomyopathy after giving birth.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11625542

• Bromocriptine added to standard therapy for postpartum heart failure (Global PPCM)

  A large, multi-country trial will test whether adding bromocriptine to usual heart failure treatment improves outcomes for women with postpartum cardiomyopathy.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11625541

• Population genomics in peripartum cardiomyopathy

  A gene-focused study to understand why some women develop heart failure around and after pregnancy, with an emphasis on African ancestry.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11623271

• SGLT2 inhibitors for pediatric Duchenne-related cardiomyopathy

  A pediatric-focused study tests whether a diabetes drug class (SGLT2 inhibitors) can help heart disease linked to Duchenne muscular dystrophy in children and young adults.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11607308

• Discovery of rare genetic variants linked to dilated cardiomyopathy using big biobank data

  A large-scale genetic study will look for rare gene variants that affect dilated cardiomyopathy to improve how we diagnose and manage the condition.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11511735

• Mechanisms linking the frail sarcomere to noncompaction cardiomyopathy

  This grant studies how changes in a heart muscle protein called MYH7 may lead to a form of heart disease called left ventricular noncompaction, using patient-derived stem cells and lab-made heart tissues.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11468167

• PRDM16-linked heart disease in 1p36 deletion syndrome

  A research project aims to find treatments for a genetic form of heart disease linked to 1p36 deletion syndrome and PRDM16 mutations, focusing on why women are affected more and how to intervene early.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11450960

• Cellular and Molecular Clues to LVNC Heart Disease

  A study on why a childhood heart condition called LVNC develops, using genetic tools and a new mouse model to uncover the cellular changes and heart cell interactions involved.

  NIH research University of Houston · Houston, United States · NIH-11450200

• Lipotoxicity and spleen signals in obesity-related heart disease

  A study in mice explores how fat-related damage in the spleen might affect obesity-driven heart disease and aim to find new ways to help people with obesity cardiomyopathy.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11449393

• Titin Gene Variants and Heart Disease: Understanding Who Might Be Affected

  Researchers will study how TTN truncating variants affect heart health in people, with the goal of guiding future care for those with these genetic findings.

  NIH research Geisinger Clinic · Danville, United States · NIH-11446134

• Understanding how muscle ribosome mutations cause severe neonatal dilated cardiomyopathy and ways to treat it

  This grant focuses on a rare genetic heart condition in newborns caused by mutations in a muscle-specific ribosomal protein, with hopes to find new ways to diagnose and treat it.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11433394

• PET imaging to map heart inflammation and predict arrhythmogenic cardiomyopathy risk

  A heart-imaging study using PET scans with a glucose tracer to help predict who with a genetic heart disease might develop dangerous symptoms.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11432341

• Defining and Targeting DELE1-Driven Mitochondrial Stress in Heart Disease

  A project to understand and block how a mitochondrial stress sensor called DELE1 contributes to heart disease, with potential new ways to protect the heart.

  NIH research University of Virginia · Charlottesville, United States · NIH-11431714

• Gene therapy for FLNC-related heart disease

  A patient-focused overview of testing gene-delivery methods to restore FLNC protein in people with FLNC-related cardiomyopathy.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11427270

• Nuclear rupture and repair in LMNA-related cardiomyopathy

  A study to understand how defects in the nuclear envelope cause a dangerous heart disease and to test new ways to repair it.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11427136

• Unlocking how rare genetic changes cause dilated cardiomyopathy

  A large study will look at genetic data from many people to understand which rare variants affect dilated cardiomyopathy and how this changes risk and treatment.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11420431

• New small molecule to prevent and treat heart problems in Duchenne muscular dystrophy

  A new drug-like molecule is being tested in animal models to help protect the heart and muscles in Duchenne muscular dystrophy.

  NIH research Novomedix, INC. · San Diego, United States · NIH-11419291

• CPNE5 and blood vessel leaks in sepsis-related heart failure

  This grant studies a protein called CPNE5 and how it affects blood vessel leaks that can lead to heart problems during severe infections like sepsis.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11419035

• Prospective study on cirrhotic heart problems in adults and kids

  Aimed at understanding how cirrhosis affects heart function in people with liver disease, through careful heart tests and patient data.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11417934

• Using ECG and AI to find childhood cancer survivors at risk for late cardiomyopathy

  This project uses routine ECG tracings plus artificial intelligence to spot childhood cancer survivors who may develop heart muscle disease years later.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11417087

• SGLT inhibitors for non-obstructive hypertrophic cardiomyopathy

  A testing of a diabetes drug class (SGLT2 inhibitors) to help people with non-obstructive hypertrophic cardiomyopathy feel better and reduce heart-related problems.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11412600

• Using big biobanks to understand rare gene changes in hypertrophic cardiomyopathy

  A large study will look at genetic data and health information from many people to better understand how rare gene changes influence hypertrophic cardiomyopathy and its risks.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11411152

• Testing pediatric cardiomyopathy genes using fruit fly models

  This project uses fruit flies to find which genetic changes found in children with cardiomyopathy actually harm the heart.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11403792

• Biological treatment to reduce ventricular arrhythmias in a pig model of heart disease

  Aims to test if delivering heart-cell–derived exosomes into damaged heart tissue can reduce scar and prevent dangerous ventricular rhythms in a porcine model of chronic ischemic cardiomyopathy.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11402761

• Cardioprotective treatment choices for DLBCL patients at risk of heart damage

  Atrially, this study tests two heart-protecting drugs given during cancer treatment to see which best prevents heart problems in patients with diffuse large B-cell lymphoma who are at higher risk for heart damage.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11402640

• Lamin A/C and the heart: how LMNA mutations cause cardiomyopathy

  This grant tests two ideas about why LMNA mutations lead to dilated cardiomyopathy in adults, with goals that could point to new ways to treat the condition.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11401202

• Understanding early drivers and targets to treat severe ARVD/C

  This study aims to uncover how inflammation and immune responses contribute to a severe form of a genetic heart disease in young people and to identify potential therapies.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11396233

• Understanding heart disease in hypertrophic cardiomyopathy through heart tissue and blood analysis

  Researchers are studying people with hypertrophic cardiomyopathy to see how genes and signaling in heart tissue and blood relate to disease progression and risk of serious heart problems.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11395391

• Molecular tie between the heart’s interior scaffold and its nucleus in ARVC

  This grant studies how defects in a heart cell protein called PKP2 may disrupt the nucleus and trigger dangerous arrhythmias in people with ARVC.

  NIH research University of Rochester · Rochester, United States · NIH-11395368

Related topics

Quick answers

How many Cardiomyopathy clinical trials are recruiting right now?

21, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in United States (11 trials), France (2 trials), China (2 trials), Italy (2 trials), Spain (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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