Understanding TRPC6 to Prevent Heart Issues in Breast Cancer Patients Receiving Chemotherapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on the TRPC6 gene to predict and prevent cardiac toxicity and heart failure in patients undergoing chemotherapy for breast cancer. By collecting blood samples from patients, the study aims to identify genetic variants associated with doxorubicin-related cardiotoxicity and monitor changes in heart function. The research will also review patients' medical records to gather comprehensive data on cardiac health. The ultimate goal is to enable early interventions and identify new therapeutic targets to protect long-term cardiac health in these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18 years of age or older
* Any breast cancer patient initiating doxorubicin/other anthracycline and patients receiving trastuzumab without doxorubicin/anthracycline in the neoadjuvant/adjuvant setting
* An understanding of the protocol and its requirements, risks, and discomforts
* The ability and willingness to sign an informed consent
* Diagnosed with therapy related cardiotoxicity defined as; cardiomyopathy, symptomatic heart failure, asymptomatic reduced systolic function, acute coronary syndrome, myocardial infarction, critical limb ischemia, cardiac arrhythmias or myocarditis possibly related to prior cancer treatment OR completed chemotherapy with no cardiotoxicity at least two years post treatment OR patients with cancer who will be initiating systemic therapy with potentially cardiotoxic medications. This will include doxorubicin chemotherapy, or trastuzumab.
* Healthy, non-pregnant, adult subjects who weigh at least 110 pounds

Exclusion Criteria:

* Inability on the part of the patient to understand the informed consent or be compliant with the protocol
* Anemia with hemoglobin less than 8
* Patients not willing to undergo a blood draw
* Patients with stage IV or distant metastatic breast cancer

Where it's running

• University of Florida
  Gainesville, Florida, United States Recruiting
• Mayo Clinic in Florida
  Jacksonville, Florida, United States Recruiting

Study contacts

• Principal investigator: Nadine Norton, Ph.D. — Mayo Clinic
• Study coordinator: Clinical Trials Referral Office
• Email: mayocliniccancerstudies@mayo.edu
• Phone: 855-776-0015

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.