Global bromocriptine trial to help postpartum heart failure patients
Official title: 1/2 GLobal trial Of Bromocriptine for PeriPartum CardioMyopathy (GLOBal PPCM)
Funded at University of Alabama at Birmingham · NIH-11625550 · Data updated 2026-11-12
A large international trial tests whether adding bromocriptine to standard heart failure treatment improves outcomes for new mothers with a specific pregnancy-related heart condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | September 15, 2026 |
| Project end | August 31, 2033 |
| Funding year | 2026 |
| Award (this year) | $31,320 |
| NIH project number | 3UG3HL177574-01A1S9 |
| Project ID | NIH-11625550 on NIH RePORTER |
Who could benefit from this research
✓Could help
Postpartum women diagnosed with peripartum cardiomyopathy who are receiving standard heart failure treatment and can participate at one of the study sites.
✕Less likely to help
Some participants may not experience improvement and may face potential lactation effects or other bromocriptine-related risks.
What this research studies
This study will enroll about 650 postpartum patients with peripartum cardiomyopathy across many sites in low- and middle-income countries. Participants will be randomly assigned to receive either bromocriptine or a placebo in addition to their usual heart failure therapies, and will be followed for six months to track key health outcomes. The goal is to see if the add-on therapy reduces maternal death, severe heart problems, or hospitalizations, while monitoring safety for both mother and baby. Patients will be counseled about potential effects on lactation and safety will be closely watched, with data collected to inform future care guidance.
Why it matters
Potential benefit: If successful, the trial could lead to a new treatment option that improves survival and heart function for women after childbirth.
How similar studies have gone: Early, smaller studies hinted at possible benefits, but this is a large, definitive trial.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Tita, Alan Thevenet N. — University of Alabama at Birmingham
- Study coordinator: Tita, Alan Thevenet N.
Related research
Other NIH-funded projects on the same topics.
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Global bromocriptine trial for postpartum cardiomyopathy
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with peripartum cardiomyopathy.
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Global Bromocriptine Add-on for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding the dopamine agonist bromocriptine to standard heart failure care helps postpartum women with a specific heart condition.
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Global Bromocriptine Trial for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding bromocriptine to standard heart-failure care helps women with postpartum cardiomyopathy.
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Bromocriptine as add-on therapy for postpartum cardiomyopathy across multiple sites
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with postpartum cardiomyopathy.
-
Global Bromocriptine Trial to Help Postpartum Heart Failure
A large international study will test whether adding bromocriptine to standard heart failure treatment helps women with postpartum cardiomyopathy.
-
Bromocriptine Added to Standard Care for Postpartum Heart Muscle Disease (GLOBal PPCM)
A large international study will test whether adding the drug bromocriptine to standard heart failure treatment helps women with postpartum cardiomyopathy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.