Global Bromocriptine Trial for Postpartum Heart Failure (GLOBal PPCM)
Official title: 1/2 GLobal trial Of Bromocriptine for PeriPartum CardioMyopathy (GLOBal PPCM)
Funded at University of Alabama at Birmingham · NIH-11625542 · Data updated 2026-11-12
This study tests whether adding bromocriptine to standard heart failure treatment helps women with peripartum cardiomyopathy after giving birth.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | September 15, 2026 |
| Project end | August 31, 2033 |
| Funding year | 2026 |
| Award (this year) | $41,688 |
| NIH project number | 3UG3HL177574-01A1S2 |
| Project ID | NIH-11625542 on NIH RePORTER |
Who could benefit from this research
✓Could help
Postpartum women diagnosed with PPCM who are eligible for standard heart-failure therapy and willing to participate in a multicenter randomized trial.
✕Less likely to help
Patients who cannot take bromocriptine or who do not meet trial criteria may not experience a benefit and could miss alternatives available outside the study.
What this research studies
If you recently had a baby and have PPCM, you may be invited to join a large international trial. Participants would be randomized to receive either bromocriptine or a placebo for several months, in addition to their usual heart-care medicines. The trial aims to see whether this add-on therapy reduces the risk of death, severe heart problems, or hospital readmission within six months. The study will monitor safety for both mothers and their babies, including any effects on lactation. It will involve at least 18 sites across 15 lower- and middle-income countries.
Why it matters
Potential benefit: If bromocriptine proves beneficial, future patients with PPCM could have improved heart outcomes and potentially safer, more effective treatment options.
How similar studies have gone: Preliminary small studies suggested potential benefits, but this is a large, confirmatory trial to establish safety and efficacy.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Tita, Alan Thevenet N. — University of Alabama at Birmingham
- Study coordinator: Tita, Alan Thevenet N.
Related research
Other NIH-funded projects on the same topics.
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Global bromocriptine trial for postpartum cardiomyopathy
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with peripartum cardiomyopathy.
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Global Bromocriptine Add-on for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding the dopamine agonist bromocriptine to standard heart failure care helps postpartum women with a specific heart condition.
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Global Bromocriptine Trial for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding bromocriptine to standard heart-failure care helps women with postpartum cardiomyopathy.
-
Bromocriptine as add-on therapy for postpartum cardiomyopathy across multiple sites
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with postpartum cardiomyopathy.
-
Global bromocriptine trial to help postpartum heart failure patients
A large international trial tests whether adding bromocriptine to standard heart failure treatment improves outcomes for new mothers with a specific pregnancy-related heart condition.
-
Global Bromocriptine Trial to Help Postpartum Heart Failure
A large international study will test whether adding bromocriptine to standard heart failure treatment helps women with postpartum cardiomyopathy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.