Bromocriptine added to standard therapy for postpartum heart failure (Global PPCM)
Official title: 1/2 GLobal trial Of Bromocriptine for PeriPartum CardioMyopathy (GLOBal PPCM)
Funded at University of Alabama at Birmingham · NIH-11625541 · Data updated 2026-11-12
A large, multi-country trial will test whether adding bromocriptine to usual heart failure treatment improves outcomes for women with postpartum cardiomyopathy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | September 15, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $34,560 |
| NIH project number | 3UG3HL177574-01A1S1 |
| Project ID | NIH-11625541 on NIH RePORTER |
Who could benefit from this research
✓Could help
Postpartum women diagnosed with peripartum cardiomyopathy who are receiving standard heart failure therapy and are able to participate at one of the 18 sites.
✕Less likely to help
Women with contraindications to bromocriptine or those unable to participate at any of the study sites may not benefit.
What this research studies
If you’ve had a baby and are dealing with cardiomyopathy after delivery, this trial will compare bromocriptine plus standard care to placebo plus standard care in 650 women across 18 sites in 15 low- and middle-income countries. Participants are randomly assigned to receive either the medication or a matching placebo for a set period, alongside the usual heart failure treatments. The main goal is to see whether bromocriptine reduces death, persistent severe heart impairment, or hospital readmission within six months. The study will also monitor safety for mothers and infants, including effects on lactation.
Why it matters
Potential benefit: If successful, the approach could become a new add-on option to improve survival and heart recovery for women with PPCM.
How similar studies have gone: Preliminary studies suggested potential benefits of bromocriptine, but there is a need for a large confirmatory trial.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Tita, Alan Thevenet N. — University of Alabama at Birmingham
- Study coordinator: Tita, Alan Thevenet N.
Related research
Other NIH-funded projects on the same topics.
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Global bromocriptine trial for postpartum cardiomyopathy
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with peripartum cardiomyopathy.
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Global Bromocriptine Add-on for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding the dopamine agonist bromocriptine to standard heart failure care helps postpartum women with a specific heart condition.
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Global Bromocriptine Trial for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding bromocriptine to standard heart-failure care helps women with postpartum cardiomyopathy.
-
Bromocriptine as add-on therapy for postpartum cardiomyopathy across multiple sites
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with postpartum cardiomyopathy.
-
Global bromocriptine trial to help postpartum heart failure patients
A large international trial tests whether adding bromocriptine to standard heart failure treatment improves outcomes for new mothers with a specific pregnancy-related heart condition.
-
Global Bromocriptine Trial to Help Postpartum Heart Failure
A large international study will test whether adding bromocriptine to standard heart failure treatment helps women with postpartum cardiomyopathy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.