Global Bromocriptine Trial for Postpartum Heart Disease (PPCM)
Official title: 1/2 GLobal trial Of Bromocriptine for PeriPartum CardioMyopathy (GLOBal PPCM)
Funded at University of Alabama at Birmingham · NIH-11625543 · Data updated 2026-11-12
A large international trial will test whether adding bromocriptine to standard heart-failure treatment improves outcomes for women with postpartum cardiomyopathy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | September 15, 2026 |
| Project end | August 31, 2033 |
| Funding year | 2026 |
| Award (this year) | $32,400 |
| NIH project number | 3UG3HL177574-01A1S3 |
| Project ID | NIH-11625543 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women who recently gave birth and have diagnosed PPCM, within a defined postpartum window, who are able to receive standard heart-failure therapy.
✕Less likely to help
Patients without PPCM or those unable to take standard heart-failure medications may not benefit from this intervention.
What this research studies
This trial will enroll about 650 postpartum patients with PPCM across at least 18 sites in 15 LMICs. Participants will be randomly assigned to receive either bromocriptine or a matching placebo in addition to standard heart-failure therapy, and will be followed for six months to monitor major outcomes. The study aims to determine if adding bromocriptine reduces maternal death, persistent poor heart function, or hospitalization for heart failure, while also carefully tracking safety for mothers and babies. All sites will follow consistent protocols and safety monitoring to ensure reliable results. If successful, findings could inform new treatment guidelines for PPCM globally.
Why it matters
Potential benefit: If successful, the trial could improve survival and heart-function recovery for women with PPCM and clarify safety for mothers and infants when using bromocriptine.
How similar studies have gone: Preliminary small studies suggested possible benefits, but a large, diverse trial is needed to establish effectiveness and safety.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Tita, Alan Thevenet N. — University of Alabama at Birmingham
- Study coordinator: Tita, Alan Thevenet N.
Related research
Other NIH-funded projects on the same topics.
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Global bromocriptine trial for postpartum cardiomyopathy
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with peripartum cardiomyopathy.
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Global Bromocriptine Add-on for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding the dopamine agonist bromocriptine to standard heart failure care helps postpartum women with a specific heart condition.
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Global Bromocriptine Trial for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding bromocriptine to standard heart-failure care helps women with postpartum cardiomyopathy.
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Bromocriptine as add-on therapy for postpartum cardiomyopathy across multiple sites
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with postpartum cardiomyopathy.
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Global bromocriptine trial to help postpartum heart failure patients
A large international trial tests whether adding bromocriptine to standard heart failure treatment improves outcomes for new mothers with a specific pregnancy-related heart condition.
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Global Bromocriptine Trial to Help Postpartum Heart Failure
A large international study will test whether adding bromocriptine to standard heart failure treatment helps women with postpartum cardiomyopathy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.