Bromocriptine as add-on therapy for postpartum cardiomyopathy across multiple sites
Official title: 1/2 GLobal trial Of Bromocriptine for PeriPartum CardioMyopathy (GLOBal PPCM)
Funded at University of Alabama at Birmingham · NIH-11625551 · Data updated 2026-11-12
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with postpartum cardiomyopathy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | September 15, 2026 |
| Project end | August 31, 2033 |
| Funding year | 2026 |
| Award (this year) | $31,320 |
| NIH project number | 3UG3HL177574-01A1SA |
| Project ID | NIH-11625551 on NIH RePORTER |
Who could benefit from this research
✓Could help
Postpartum patients with peripartum cardiomyopathy who are already receiving standard heart failure therapy and are eligible for a randomized, placebo-controlled trial.
✕Less likely to help
Women with contraindications to bromocriptine or those not fitting the postpartum cardiomyopathy criteria may not benefit.
What this research studies
If you recently had a baby and have cardiomyopathy, this trial offers a potential extra medicine on top of your usual heart failure care. It will enroll about 650 postpartum patients across many sites in low- and middle-income countries and compare bromocriptine to a placebo, alongside standard therapy. The main goal is to see if this add-on treatment reduces serious outcomes within six months after randomization. The study also closely monitors safety for both mothers and babies, including effects on lactation. Participants will receive regular follow-up and careful medical oversight throughout the trial.
Why it matters
Potential benefit: If successful, the treatment could improve heart function and reduce risk of death or hospital readmission.
How similar studies have gone: Preliminary small studies and animal data suggested potential benefit, but a large-scale trial is needed to confirm efficacy and safety.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Tita, Alan Thevenet N. — University of Alabama at Birmingham
- Study coordinator: Tita, Alan Thevenet N.
Related research
Other NIH-funded projects on the same topics.
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Global bromocriptine trial for postpartum cardiomyopathy
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with peripartum cardiomyopathy.
-
Global Bromocriptine Add-on for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding the dopamine agonist bromocriptine to standard heart failure care helps postpartum women with a specific heart condition.
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Global Bromocriptine Trial for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding bromocriptine to standard heart-failure care helps women with postpartum cardiomyopathy.
-
Global bromocriptine trial to help postpartum heart failure patients
A large international trial tests whether adding bromocriptine to standard heart failure treatment improves outcomes for new mothers with a specific pregnancy-related heart condition.
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Global Bromocriptine Trial to Help Postpartum Heart Failure
A large international study will test whether adding bromocriptine to standard heart failure treatment helps women with postpartum cardiomyopathy.
-
Bromocriptine Added to Standard Care for Postpartum Heart Muscle Disease (GLOBal PPCM)
A large international study will test whether adding the drug bromocriptine to standard heart failure treatment helps women with postpartum cardiomyopathy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.