Bromocriptine Added to Standard Care for Postpartum Heart Muscle Disease (GLOBal PPCM)
Official title: 1/2 GLobal trial Of Bromocriptine for PeriPartum CardioMyopathy (GLOBal PPCM)
Funded at University of Alabama at Birmingham · NIH-11625548 · Data updated 2026-11-12
A large international study will test whether adding the drug bromocriptine to standard heart failure treatment helps women with postpartum cardiomyopathy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | September 15, 2026 |
| Project end | August 31, 2033 |
| Funding year | 2026 |
| Award (this year) | $30,780 |
| NIH project number | 3UG3HL177574-01A1S7 |
| Project ID | NIH-11625548 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women who have recently developed postpartum cardiomyopathy and are receiving standard heart failure treatment could be eligible.
✕Less likely to help
Some participants may not experience a clinical benefit and could experience side effects from bromocriptine or from stopping lactation.
What this research studies
This trial will enroll about 650 postpartum patients with cardiomyopathy across at least 18 sites in 15 low- and middle-income countries. Participants will be randomly assigned to receive either bromocriptine or a placebo, in addition to their usual heart failure care. The main goal is to see if the bromocriptine add-on reduces death, persistent heart damage, or hospital readmission within six months. The study will also closely monitor safety for both mothers and babies, including effects on lactation. All sites will follow rigorous monitoring and data collection to ensure reliable results.
Why it matters
Potential benefit: If successful, the trial could establish bromocriptine as a proven add-on therapy to improve survival and heart function in PPCM.
How similar studies have gone: Preliminary and smaller studies suggested potential benefits, but this large trial is designed to provide definitive evidence.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Tita, Alan Thevenet N. — University of Alabama at Birmingham
- Study coordinator: Tita, Alan Thevenet N.
Related research
Other NIH-funded projects on the same topics.
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Global bromocriptine trial for postpartum cardiomyopathy
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with peripartum cardiomyopathy.
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Global Bromocriptine Add-on for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding the dopamine agonist bromocriptine to standard heart failure care helps postpartum women with a specific heart condition.
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Global Bromocriptine Trial for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding bromocriptine to standard heart-failure care helps women with postpartum cardiomyopathy.
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Bromocriptine as add-on therapy for postpartum cardiomyopathy across multiple sites
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with postpartum cardiomyopathy.
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Global bromocriptine trial to help postpartum heart failure patients
A large international trial tests whether adding bromocriptine to standard heart failure treatment improves outcomes for new mothers with a specific pregnancy-related heart condition.
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Global Bromocriptine Trial to Help Postpartum Heart Failure
A large international study will test whether adding bromocriptine to standard heart failure treatment helps women with postpartum cardiomyopathy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.