Bromocriptine addition for postpartum cardiomyopathy in a global trial
Official title: 1/2 GLobal trial Of Bromocriptine for PeriPartum CardioMyopathy (GLOBal PPCM)
Funded at University of Alabama at Birmingham · NIH-11625544 · Data updated 2026-11-12
A large international study will test whether adding bromocriptine to standard heart failure therapy helps women after childbirth who have PPCM.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | September 15, 2026 |
| Project end | August 31, 2033 |
| Funding year | 2026 |
| Award (this year) | $32,940 |
| NIH project number | 3UG3HL177574-01A1S4 |
| Project ID | NIH-11625544 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women who have recently given birth and have a diagnosis of PPCM, receiving standard heart failure therapy, and able to participate at one of the participating sites.
✕Less likely to help
Women without PPCM or those unable to receive standard heart failure treatment may not benefit from this trial.
What this research studies
This trial enrolls about 650 postpartum PPCM patients across at least 18 sites in 15 lower- and middle-income countries. Participants will be randomly assigned to receive either bromocriptine or a matching placebo, in addition to their standard heart failure treatment. The study will follow patients for six months to see whether bromocriptine reduces the risk of death, persistent severe heart dysfunction, or hospital readmission, while also monitoring safety for mothers and babies. Some lactation effects may occur, and infant safety will be evaluated as part of the safety assessments. Results could inform guidelines on whether bromocriptine should be added to routine PPCM care in diverse settings.
Why it matters
Potential benefit: If successful, this could improve survival and heart function for many women with PPCM.
How similar studies have gone: Previous small studies and animal data suggested potential benefits, but this is a large definitive trial.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Tita, Alan Thevenet N. — University of Alabama at Birmingham
- Study coordinator: Tita, Alan Thevenet N.
Related research
Other NIH-funded projects on the same topics.
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Global bromocriptine trial for postpartum cardiomyopathy
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with peripartum cardiomyopathy.
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Global Bromocriptine Add-on for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding the dopamine agonist bromocriptine to standard heart failure care helps postpartum women with a specific heart condition.
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Global Bromocriptine Trial for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding bromocriptine to standard heart-failure care helps women with postpartum cardiomyopathy.
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Bromocriptine as add-on therapy for postpartum cardiomyopathy across multiple sites
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with postpartum cardiomyopathy.
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Global bromocriptine trial to help postpartum heart failure patients
A large international trial tests whether adding bromocriptine to standard heart failure treatment improves outcomes for new mothers with a specific pregnancy-related heart condition.
-
Global Bromocriptine Trial to Help Postpartum Heart Failure
A large international study will test whether adding bromocriptine to standard heart failure treatment helps women with postpartum cardiomyopathy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.