Global bromocriptine trial for postpartum heart muscle disease
Official title: 1/2 GLobal trial Of Bromocriptine for PeriPartum CardioMyopathy (GLOBal PPCM)
Funded at University of Alabama at Birmingham · NIH-11625547 · Data updated 2026-11-12
A large international study will test whether adding bromocriptine to standard heart-failure treatment helps women with peripartum cardiomyopathy after delivery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | September 15, 2026 |
| Project end | August 31, 2033 |
| Funding year | 2026 |
| Award (this year) | $32,206 |
| NIH project number | 3UG3HL177574-01A1S6 |
| Project ID | NIH-11625547 on NIH RePORTER |
Who could benefit from this research
✓Could help
Postpartum women diagnosed with peripartum cardiomyopathy who are receiving standard heart-failure therapy and have the potential to participate in a multicenter international trial.
✕Less likely to help
Women without PPCM or who cannot safely take bromocriptine due to contraindications or lactation considerations may not benefit.
What this research studies
This trial will enroll about 650 postpartum patients with PPCM at multiple sites in low- and middle-income countries. Participants will be randomly assigned to receive either bromocriptine or a placebo, in addition to their usual heart-failure medicines. The study will follow them for six months to see who dies, has persistent severe heart impairment, or is readmitted for heart failure. A key safety focus is whether bromocriptine affects lactation and infant safety. All sites will use standard care alongside the study drug or placebo to determine the added value and safety of bromocriptine in this condition.
Why it matters
Potential benefit: If successful, the trial could establish a safe, effective add-on therapy to improve survival and heart function for women with PPCM.
How similar studies have gone: Preliminary studies and animal data suggested potential benefit, but a large-scale trial is needed to confirm efficacy and safety.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Tita, Alan Thevenet N. — University of Alabama at Birmingham
- Study coordinator: Tita, Alan Thevenet N.
Related research
Other NIH-funded projects on the same topics.
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Global bromocriptine trial for postpartum cardiomyopathy
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with peripartum cardiomyopathy.
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Global Bromocriptine Add-on for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding the dopamine agonist bromocriptine to standard heart failure care helps postpartum women with a specific heart condition.
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Global Bromocriptine Trial for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding bromocriptine to standard heart-failure care helps women with postpartum cardiomyopathy.
-
Bromocriptine as add-on therapy for postpartum cardiomyopathy across multiple sites
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with postpartum cardiomyopathy.
-
Global bromocriptine trial to help postpartum heart failure patients
A large international trial tests whether adding bromocriptine to standard heart failure treatment improves outcomes for new mothers with a specific pregnancy-related heart condition.
-
Global Bromocriptine Trial to Help Postpartum Heart Failure
A large international study will test whether adding bromocriptine to standard heart failure treatment helps women with postpartum cardiomyopathy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.