Global bromocriptine trial for postpartum cardiomyopathy
Official title: 1/2 GLobal trial Of Bromocriptine for PeriPartum CardioMyopathy (GLOBal PPCM)
Funded at University of Alabama at Birmingham · NIH-11625554 · Data updated 2026-11-12
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with peripartum cardiomyopathy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | September 15, 2026 |
| Project end | August 31, 2033 |
| Funding year | 2026 |
| Award (this year) | $31,320 |
| NIH project number | 3UG3HL177574-01A1SD |
| Project ID | NIH-11625554 on NIH RePORTER |
Who could benefit from this research
✓Could help
Postpartum women diagnosed with PPCM who are receiving standard heart failure treatment and are eligible for the trial at participating sites.
✕Less likely to help
Women who do not meet inclusion criteria or have contraindications to bromocriptine may not benefit.
What this research studies
This trial will enroll about 650 postpartum patients with PPCM across at least 18 sites in 15 lower- and middle-income countries. Participants will be randomly assigned to receive either bromocriptine or a matching placebo in addition to their usual heart failure therapies. The primary goal is to see if bromocriptine reduces the risk of death, severe heart dysfunction, or hospital readmission within six months. The study will also monitor safety for mothers and babies, including potential effects on lactation. All sites follow standard medical care while participating in this add-on therapy investigation.
Why it matters
Potential benefit: If successful, the trial could show that bromocriptine adds meaningful protection against serious PPCM outcomes.
How similar studies have gone: Preliminary studies and animal data suggested potential benefits, but a large, well-controlled trial is needed to confirm safety and effectiveness.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Tita, Alan Thevenet N. — University of Alabama at Birmingham
- Study coordinator: Tita, Alan Thevenet N.
Related research
Other NIH-funded projects on the same topics.
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Global Bromocriptine Add-on for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding the dopamine agonist bromocriptine to standard heart failure care helps postpartum women with a specific heart condition.
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Global Bromocriptine Trial for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding bromocriptine to standard heart-failure care helps women with postpartum cardiomyopathy.
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Bromocriptine as add-on therapy for postpartum cardiomyopathy across multiple sites
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with postpartum cardiomyopathy.
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Global bromocriptine trial to help postpartum heart failure patients
A large international trial tests whether adding bromocriptine to standard heart failure treatment improves outcomes for new mothers with a specific pregnancy-related heart condition.
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Global Bromocriptine Trial to Help Postpartum Heart Failure
A large international study will test whether adding bromocriptine to standard heart failure treatment helps women with postpartum cardiomyopathy.
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Bromocriptine Added to Standard Care for Postpartum Heart Muscle Disease (GLOBal PPCM)
A large international study will test whether adding the drug bromocriptine to standard heart failure treatment helps women with postpartum cardiomyopathy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.