Global Bromocriptine Trial to Help Postpartum Heart Failure
Official title: 1/2 GLobal trial Of Bromocriptine for PeriPartum CardioMyopathy (GLOBal PPCM)
Funded at University of Alabama at Birmingham · NIH-11625549 · Data updated 2026-11-12
A large international study will test whether adding bromocriptine to standard heart failure treatment helps women with postpartum cardiomyopathy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | September 15, 2026 |
| Project end | August 31, 2033 |
| Funding year | 2026 |
| Award (this year) | $31,320 |
| NIH project number | 3UG3HL177574-01A1S8 |
| Project ID | NIH-11625549 on NIH RePORTER |
Who could benefit from this research
✓Could help
Postpartum women diagnosed with PPCM who have started standard heart failure treatment and are able to participate at one of the participating sites.
✕Less likely to help
Women who do not fit the PPCM diagnosis or cannot participate due to safety concerns or contraindications may not benefit.
What this research studies
This trial will enroll about 650 postpartum women with PPCM across many sites in low- and middle-income countries. Participants will be randomly assigned to receive either bromocriptine or a placebo, in addition to their usual heart failure care. The study will follow them for six months to see if the treatment reduces death, severe heart dysfunction, or hospital readmission, while also monitoring safety for both mothers and babies. Bromocriptine’s potential effect on lactation will be carefully evaluated as part of safety analyses. All sites will provide standard medical therapy to every participant, ensuring everyone receives current best care.
Why it matters
Potential benefit: If successful, the trial could establish bromocriptine as a proven add-on therapy to improve survival and heart function in PPCM.
How similar studies have gone: Earlier small studies hinted at benefit, but this large trial is designed to provide stronger evidence.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Tita, Alan Thevenet N. — University of Alabama at Birmingham
- Study coordinator: Tita, Alan Thevenet N.
Related research
Other NIH-funded projects on the same topics.
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Global bromocriptine trial for postpartum cardiomyopathy
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with peripartum cardiomyopathy.
-
Global Bromocriptine Add-on for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding the dopamine agonist bromocriptine to standard heart failure care helps postpartum women with a specific heart condition.
-
Global Bromocriptine Trial for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding bromocriptine to standard heart-failure care helps women with postpartum cardiomyopathy.
-
Bromocriptine as add-on therapy for postpartum cardiomyopathy across multiple sites
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with postpartum cardiomyopathy.
-
Global bromocriptine trial to help postpartum heart failure patients
A large international trial tests whether adding bromocriptine to standard heart failure treatment improves outcomes for new mothers with a specific pregnancy-related heart condition.
-
Bromocriptine Added to Standard Care for Postpartum Heart Muscle Disease (GLOBal PPCM)
A large international study will test whether adding the drug bromocriptine to standard heart failure treatment helps women with postpartum cardiomyopathy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.