Using advanced heart MRI to improve diagnosis and risk prediction for rare cardiomyopathies
Official title: Multimodality Imaging (Cardiovascular Magnetic Resonance Imaging, Echocardiography, and Nuclear Medicine Imaging) in the Screening, Diagnosis and Risk Stratification of Rare Cardiomyopathies - a Multicenter Study
Run by Chinese Academy of Medical Sciences, Fuwai Hospital · NCT07336394 · Data updated 2026-11-12
This project tests whether advanced cardiac MRI techniques can help diagnose and predict future risk for people with rare heart muscle diseases like Danon, Fabry, cardiac amyloidosis, Noonan syndrome, and cardiac sarcoidosis.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Chinese Academy of Medical Sciences, Fuwai Hospital Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Beijing) |
| Status | Recruiting |
| Started | January 1, 2010 |
| Main results expected | December 30, 2028 |
| Study ends | December 30, 2030 |
| Registry record updated | January 21, 2026 |
| Trial ID | NCT07336394 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people with a clinical suspicion of a rare cardiomyopathy who have undergone a cardiac MRI since 2010 and can provide imaging data or attend participating centers for imaging review.
✕Probably not a fit
Patients with severe arrhythmia or severe primary valvular disease (which are listed exclusions) and those without prior CMR imaging or unavailable images are unlikely to gain benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational project applies novel cardiac magnetic resonance (CMR) biomarkers to patients with suspected rare cardiomyopathies who have had CMR scans since 2010. Researchers will analyze quantitative techniques such as T1/T2 mapping, extracellular volume (ECV) fraction, feature-tracking strain, and refined late gadolinium enhancement patterns to characterize tissue changes and subtle functional abnormalities. The goal is to improve diagnostic precision and generate individualized risk profiles that could guide timing of treatment and specialist referral. Data will be collected and compared across several tertiary cardiovascular centers to validate these imaging markers in uncommon disease subtypes.
Why it matters
Potential benefit: If successful, patients could receive more accurate, noninvasive diagnoses and clearer personalized risk information that speeds appropriate treatment and specialist referral.
How similar studies have gone: Similar CMR mapping and ECV techniques have shown promise in conditions such as cardiac amyloidosis and Fabry disease, but applying a standardized multiparametric approach across multiple rare cardiomyopathies is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who have received a cardiac magnetic resonance examination since 2010 and have a suspicion of rare cardiomyopathy. Exclusion Criteria: * Severe arrhythmia; * Severe primary cardiac valvular disease; * Refuse to participate in the study.
Where it's running
-
Fuwai Hospital
Beijing, China Recruiting
Study contacts
- Study coordinator: Minjie Lu MD, PhD
- Email: coolkan@163.com
- Phone: 01088396941
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.