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Prevalence of cardiac amyloidosis in older patients with heart failure

Cardiac Amyloidosis pRevaleNce of in OLDer Subjects Affected by Heart Failure

Observational Gérond'if · NCT06427304

This study looks at how common cardiac amyloidosis is in older patients over 80 who have been hospitalized for heart failure with thickened heart muscles.

Quick facts

Study typeObservational
Enrollment637 (estimated)
Ages80 Years and up
SexAll
SponsorGérond'if Academic / other
Locations36 sites (Paris, IIe-de-France and 35 other locations)
Trial IDNCT06427304 on ClinicalTrials.gov

What this trial studies

This observational study aims to determine the prevalence of cardiac amyloidosis in geriatric patients aged 80 years and older who have been hospitalized for heart failure with left ventricular hypertrophy. The study will recruit patients from 31 geriatric or cardiologic centers over a period of 24 months, with each participant being followed for 12 months. Data collected will include medical history, clinical data, frailty status, and results from bone scintigraphy to assess myocardial involvement. Follow-up will involve phone calls every three months to monitor hospitalizations and other health outcomes.

Who should consider this trial

Good fit: Ideal candidates are individuals aged 80 years and older who have been hospitalized for heart failure with left ventricular hypertrophy in the past year.

Not a fit: Patients who have a definite diagnosis of cardiac amyloidosis or are admitted to palliative care units may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance the understanding of cardiac amyloidosis prevalence in older adults, leading to better diagnosis and management of heart failure.

How similar studies have performed: While this study focuses on a specific age group and condition, similar observational studies have successfully identified prevalence rates of cardiac conditions in older populations.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Aged ≥ 80 years
* Hospitalised for decompensation of heart failure in the last 12 months
* Subjects with hypertrophy of the septum or left ventricle at cardiac echography (defined as ≥ 12 mm)
* Subjects able to undergo a bone scintigraphy scan
* Subjects willing to participate

Exclusion Criteria:

* Subjects refusing to participate
* Subjects admitted to palliative care unit.
* Subjects under guardianship
* Subjects with a definite diagnosis of cardiac amyloidosis

Where this trial is running

Paris, IIe-de-France and 35 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Cardiac AmyloidosisCardiac amyloidosisHeart failure with left ventricular hypertrophyPositive bone scintigraphy
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.