Evaluating amyloid burden in cardiac amyloidosis using bone scintigraphy
Official title: Analysis of the Evolution of SUVmax by Quantitative Analysis Method of Bisphosphonate Scintigraphy for the Follow-up of Patients With Transthyretin Amyloidosis Treated With Tafamidis
Run by GCS Ramsay Santé pour l'Enseignement et la Recherche · NCT04849754 · Data updated 2026-11-12
This study is testing a new way to measure amyloid buildup in the hearts of people with transthyretin cardiac amyloidosis to see if it can help doctors better track the disease and improve treatment outcomes.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | GCS Ramsay Santé pour l'Enseignement et la Recherche Academic / other |
| Locations | 1 site (Lille) |
| Status | Recruiting |
| Started | February 25, 2021 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | August 20, 2026 |
| Trial ID | NCT04849754 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults over 18 years old diagnosed with transthyretin cardiac amyloidosis confirmed by scintigraphy.
✕Probably not a fit
Patients with systemic AL amyloidosis or those under legal protection will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study focuses on improving the assessment of cardiac amyloidosis by utilizing quantitative analysis methods of bisphosphonate scintigraphy. It aims to provide a more accurate evaluation of amyloid burden and patient prognosis compared to traditional semi-quantitative methods. The study will involve patients diagnosed with transthyretin cardiac amyloidosis, and will assess the effectiveness of bone scintigraphy in monitoring disease progression over time. By enhancing diagnostic capabilities, the study seeks to contribute to better patient management and treatment outcomes.
Why it matters
Potential benefit: If successful, this study could lead to improved monitoring and treatment strategies for patients with cardiac amyloidosis.
How similar studies have gone: While there is ongoing research in the field, this specific quantitative approach to evaluating amyloid burden in cardiac amyloidosis is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient, male or female, over 18 years of age * Patient diagnosed with transthyretin cardiac amyloidosis confirmed by scintigraphy * Patient with signed consent Exclusion Criteria: * Patients with systemic AL amyloidosis * Protected patient : major under guardianship, tutorship or other legal protection, deprived of liberty by judicial or administrative decision * Pregnant or breastfeeding woman
Where it's running
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Hôpital privé Le Bois
Lille, France Recruiting
Study contacts
- Principal investigator: Fredric MOUQUET — Hôpital Privé Le Bois
- Study coordinator: Frederic MOUQUET
- Email: fmouquet@ovh.fr
- Phone: 0642377375
Similar studies
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We will test whether men over 65 who have chest pain but no coronary artery disease might have hidden cardiac amyloidosis using blood and urine tests, ECG and echocardiography, bone scintigraphy, and sometimes a heart biopsy.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.