Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Evaluating amyloid burden in cardiac amyloidosis using bone scintigraphy

Official title: Analysis of the Evolution of SUVmax by Quantitative Analysis Method of Bisphosphonate Scintigraphy for the Follow-up of Patients With Transthyretin Amyloidosis Treated With Tafamidis

Run by GCS Ramsay Santé pour l'Enseignement et la Recherche · NCT04849754 · Data updated 2026-11-12

This study is testing a new way to measure amyloid buildup in the hearts of people with transthyretin cardiac amyloidosis to see if it can help doctors better track the disease and improve treatment outcomes.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment30 (estimated)
SponsorGCS Ramsay Santé pour l'Enseignement et la Recherche
Academic / other
Locations1 site (Lille)
StatusRecruiting
StartedFebruary 25, 2021
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedAugust 20, 2026
Trial IDNCT04849754 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults over 18 years old diagnosed with transthyretin cardiac amyloidosis confirmed by scintigraphy.

Probably not a fit

Patients with systemic AL amyloidosis or those under legal protection will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on improving the assessment of cardiac amyloidosis by utilizing quantitative analysis methods of bisphosphonate scintigraphy. It aims to provide a more accurate evaluation of amyloid burden and patient prognosis compared to traditional semi-quantitative methods. The study will involve patients diagnosed with transthyretin cardiac amyloidosis, and will assess the effectiveness of bone scintigraphy in monitoring disease progression over time. By enhancing diagnostic capabilities, the study seeks to contribute to better patient management and treatment outcomes.

Why it matters

Potential benefit: If successful, this study could lead to improved monitoring and treatment strategies for patients with cardiac amyloidosis.

How similar studies have gone: While there is ongoing research in the field, this specific quantitative approach to evaluating amyloid burden in cardiac amyloidosis is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patient, male or female, over 18 years of age
* Patient diagnosed with transthyretin cardiac amyloidosis confirmed by scintigraphy
* Patient with signed consent

Exclusion Criteria:

* Patients with systemic AL amyloidosis
* Protected patient : major under guardianship, tutorship or other legal protection, deprived of liberty by judicial or administrative decision
* Pregnant or breastfeeding woman

Where it's running

  • Hôpital privé Le Bois
    Lille, France
    Recruiting

Study contacts

  • Principal investigator: Fredric MOUQUET — Hôpital Privé Le Bois
  • Study coordinator: Frederic MOUQUET
  • Email: fmouquet@ovh.fr
  • Phone: 0642377375

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.