AI-guided echocardiogram screening for cardiac amyloidosis
Official title: Artificial Intelligence Guided Echocardiographic Screening of Rare Diseases
Run by Cedars-Sinai Medical Center · NCT05139797 · Data updated 2026-11-12
This study is testing whether an AI tool can help doctors find people at high risk for cardiac amyloidosis by analyzing heart ultrasound images more accurately.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Cedars-Sinai Medical Center Academic / other |
| Locations | 1 site (Los Angeles, California) |
| Status | Recruiting |
| Started | November 18, 2021 |
| Main results expected | January 1, 2027 |
| Study ends | June 1, 2027 |
| Registry record updated | July 22, 2026 |
| Trial ID | NCT05139797 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients with a high suspicion of cardiac amyloidosis as determined by the AI algorithm.
✕Probably not a fit
Patients who decline to be seen at the specialty clinic or those who have passed away will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study evaluates the effectiveness of an artificial intelligence algorithm, EchoNet-LVH, in identifying patients at high risk for cardiac amyloidosis through echocardiographic screening. The study aims to enhance the accuracy of cardiac disease diagnosis by leveraging machine learning techniques to detect features that may be overlooked by human experts. By improving the identification of cardiac hypertrophy, the study seeks to facilitate timely and appropriate treatment for patients who may benefit from further screening. The approach addresses the limitations of traditional echocardiography, which can be subjective and variable among providers.
Why it matters
Potential benefit: If successful, this study could lead to more accurate and timely diagnoses of cardiac amyloidosis, improving patient outcomes through targeted therapies.
How similar studies have gone: Other studies have shown promise in using AI for diagnostic purposes in cardiology, suggesting that this approach may yield successful outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who have a high suspicion for cardiac amyloidosis by AI algorithm Exclusion Criteria: * Patients who decline to be seen at specialty clinic * Patients who have passed away
Where it's running
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Cedars-Sinai Medical Centre (Los Angeles)
Los Angeles, California, United States Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.