Diagnosing ATTR Cardiac Amyloidosis in Patients with Carpal Tunnel Syndrome
Prevalence and Long Tem Follow Up of ATTR Cardiac Amyloidosis in a Selected Population of Patients Operated on Carpal Tunnel Syndrome
This study is testing if patients with carpal tunnel syndrome might also have a heart condition called ATTR amyloidosis by doing tests and following them for 10 years.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 180 (estimated) |
| Ages | 50 Years and up |
| Sex | All |
| Sponsor | Helse Møre og Romsdal HF Government |
| Locations | 1 site (Ålesund, Møre og Romsdal) |
| Trial ID | NCT06458374 on ClinicalTrials.gov |
What this trial studies
This observational study involves patients who have undergone surgery for carpal tunnel syndrome at Ålesund Hospital. It aims to diagnose ATTR amyloidosis through biopsy and follow patients for 10 years to monitor for the development of cardiac amyloidosis. Participants will undergo a series of examinations, including echocardiography and genetic testing, to assess their condition and receive standard treatment as necessary. The study will provide valuable long-term data on the relationship between carpal tunnel syndrome and cardiac amyloidosis.
Who should consider this trial
Good fit: Ideal candidates are males over 50 years and females over 60 years who have had surgery for carpal tunnel syndrome at Ålesund Hospital.
Not a fit: Patients who do not consent, cannot communicate in Norwegian, or have secondary causes of carpal tunnel syndrome will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to earlier diagnosis and better management of cardiac amyloidosis in patients with carpal tunnel syndrome.
How similar studies have performed: While the specific approach of this study is novel, similar studies have shown the importance of early diagnosis of amyloidosis in related conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male \> 50 years * Female \> 60 years * operated CTS at Ålesund Hospital Exclusion Criteria: * not consented * do not speak Norwegian * secondary cause of CTS as traumatic or rheumatic * cannot be followed \> 5 years due to other medical conditions * Cardiac disease at time of operation for CTS
Where this trial is running
Ålesund, Møre og Romsdal
- Ålesund Hospital — Ålesund, Møre og Romsdal, Norway (Recruiting)
Study contacts
- Principal investigator: Torstein Hole, MD, PhD — Helse Møre og Romsdal HF and NTNU
- Study coordinator: Torstein Hole, Professor, MD, PhD
- Email: torstein.hole@helse-mr.no
- Phone: +4770105000, +4793421002
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.