Condition

Bone Loss clinical trials and research

• 21Clinical trials
• 72NIH research projects
• 23Countries

Newest Bone Loss clinical trials

All recruiting trials (21)

• All-on-6 upper jaw implants placed with stackable guided surgery and immediate loading

  This study will test whether a fully digital stackable guided surgery workflow with immediate loading works well for adults needing full-arch upper jaw (All-on-6) implants.

  Recruiting Menoufia University · Shibīn al Kawm, Menoufia · NCT07353619

• Guided Equator overdentures for the lower jaw

  This project tests whether fully guided computer-assisted implant placement with Equator attachments gives reliable implant survival and less bone loss for adults with a completely edentulous lower jaw.

  Recruiting Menoufia University · Shibīn al Kawm · NCT07196943

• How three prosthetic methods affect bone levels around dental implants

  This trial will test whether three different prosthetic approaches for posterior dental implants change marginal bone levels around the implant over one year in adults eligible for Lance implants.

  Recruiting Studio Odontoiatrico Associato Dr. P. Cicchese e L. Canullo · Roma, RM · NCT07156110

• Mandibular overdentures held by four Locator attachments versus a four-implant bar

  This study tests whether mandibular overdentures retained by four Locator attachments or by a four-implant bar better preserve jaw bone in people who have been fully toothless for at least a year.

  Recruiting Menoufia University · Al Mansurah, Menoufia · NCT07093853

• Evaluation of AdvanCore Bone Graft for Bone Healing

  This study is testing if the AdvanCore bone graft can help adults with serious bone defects heal better over a year.

  Recruiting at 2 sites Artur Salgado SA · Guimarães, Braga District and 3 other locations · NCT06736457

• Comparing high-resolution and pQCT scans to view bone and muscle structure

  This study will try high-resolution CT (HR-pQCT), pQCT, and DXA scans to see if they reveal bone and muscle microarchitecture changes in adults at risk of osteoporosis or muscle loss.

  Recruiting Centre Hospitalier Universitaire de Saint Etienne · Saint-Etienne · NCT06541548

• Custom-made implants for failed hip surgeries

  This study is testing whether custom-made hip implants can help adults who need surgery to fix problems from previous hip surgeries due to severe bone damage.

  Recruiting Istituto Ortopedico Rizzoli · Bologna · NCT06527664

• Impact of Lutein, Zeaxanthin, and Fish Oil on Health

  This study is testing if taking a daily supplement of lutein, zeaxanthin, and fish oil can help improve brain function, eye health, and bone strength in healthy adults aged 18-45 who have low eye pigment.

  Recruiting Texas A&M University · College Station, Texas · NCT06489873

• Effects of digitally made subperiosteal implants on bone loss

  This study is testing whether new digital implants can help people with severe bone loss in their upper jaw feel better and improve their dental health.

  Recruiting Menoufia University · Al Mansurah · NCT06362057

• Cohort study on the health effects of different plant-based diets

  This study is trying to see how different plant-based diets, like vegan and vegetarian, affect the health of people aged 18 to 69 in Germany and Austria.

  Recruiting at 6 sites German Federal Institute for Risk Assessment · Vienna and 7 other locations · NCT06323538

• Using bioceramic materials to repair bone defects

  This study is testing if a new type of bioceramic implant can help people heal better from bone defects compared to a standard bone implant.

  Recruiting Nanjing First Hospital, Nanjing Medical University · Nanjing, Jiangsu · NCT06249906

• Monitoring menopausal symptoms in women with gynecological cancer after ovary removal

  This study looks at how menopause symptoms and bone health change over time in women aged 18-55 with gynecological cancer who have had their ovaries removed, to find the best ways to help them feel better and prevent bone loss.

  Recruiting Anhui Provincial Hospital · Hefei, Anhui · NCT06151028

• Combining exercise and medication to reduce bone loss during weight loss in older adults

  This study is testing if combining exercise and medication can help older adults lose weight without losing bone strength.

  Recruiting at 2 sites Phase 4 Wake Forest University Health Sciences · Aurora, Colorado and 1 other locations · NCT05764733

• Comparing two surgical methods for shoulder dislocation treatment

  This study is testing which of two shoulder surgeries, the Latarjet procedure or Anatomic Glenoid Reconstruction, works better for people with significant bone loss after multiple dislocations.

  Recruiting Nova Scotia Health Authority · Halifax, Nova Scotia · NCT05658289

• Minimally invasive procedure for sinus lift using interradicular access

  This study tests a new, less invasive way to lift the sinus membrane to help people get dental implants while reducing recovery time and discomfort.

  Recruiting Universidad de Murcia · Murcia · NCT05237570

• Comparing two methods for bone ridge augmentation before dental implants

  This study is testing two different ways to help patients get enough bone for dental implants to see which method works better for healing.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT04954664

• Using risedronate to prevent bone loss after bariatric surgery

  This study is testing if the medication risedronate can help prevent bone and muscle loss in people who have had bariatric surgery.

  Recruiting Phase 3 Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT04922333

• Exploring the role of induced membranes in bone reconstruction

  This study is testing how a special surgical technique that creates a natural membrane can help improve healing in people with severe bone fractures when traditional methods don't work.

  Recruiting at 2 sites Direction Centrale du Service de Santé des Armées · Clamart and 1 other locations · NCT04883502

• Evaluating bone density and vascular calcifications after kidney transplant

  This study is looking at how bone and blood vessel health change over time in people who have recently had a kidney transplant to help improve their recovery.

  Recruiting University of Liege · Liège · NCT04713774

• Understanding induced membrane properties in bone reconstruction

  This study is testing how special membranes formed during a bone reconstruction technique can help improve healing in both children and adults.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT04246944

• International registry for long bone defects after trauma

  This study is creating a global database to collect information on patients with long bone injuries from trauma to help improve treatment options and outcomes.

  Recruiting at 14 sites AO Innovation Translation Center · Los Angeles, California and 20 other locations · NCT04112992

NIH-funded research (newest 40 of 72)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How HIV and HIV meds affect jaw bone and teeth

  This project looks at how HIV, its treatment, and immune changes may cause jawbone and tooth loss in people living with HIV.

  NIH research Emory University · Atlanta, United States · NIH-11596027

• Periodontitis and HIV treatment–related bone loss in the jaw and teeth

  This project studies how HIV and its treatment affect jawbone and tooth loss in people living with HIV, aiming to understand and reduce bone damage around teeth.

  NIH research Emory University · Atlanta, United States · NIH-11596026

• Molecular clues to bone loss from disuse

  This project looks for genes that influence bone loss when people or animals don’t move much, like during bed rest or spaceflight.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11444881

• Oral-Gut–Bone Links in Periodontitis and Bone Loss

  This research explores how gum disease could affect bone health by studying the connection between the mouth, gut, and bones in adults.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11441853

• Bone health restoration after spinal cord injury through Wnt signaling and exercise

  Aims to find a long-term way to preserve and rebuild bone in people with spinal cord injury, especially veterans, by combining exercise and bone-building signals.

  NIH research Rlr VA Medical Center · Indianapolis, United States · NIH-11421135

• Urine cadmium and bone health in older adults

  This project looks at whether long-term cadmium exposure, measured in urine, is linked to bone loss and fractures in older adults.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11420047

• Contraceptive bone loss and lead exposure in young women

  This study looks at whether a common birth control shot (DMPA) can raise levels of lead in the blood of premenopausal women.

  NIH research Michigan State University · East Lansing, United States · NIH-11396280

• Bone loss after starting HIV medicines: the role of the gut and gut bacteria

  This project looks at whether immune recovery and gut bacteria explain sudden bone loss in adults living with HIV who start antiretroviral therapy.

  NIH research Emory University · Atlanta, United States · NIH-11395102

• Exercise and bone-strengthening medication to protect bones during weight loss in older adults

  A year-long study will test whether resistance training, bone-loading exercise, and a common osteoporosis drug can help older adults lose weight without losing bone density.

  NIH research Wake Forest University · Winston-Salem, United States · NIH-11392386

• Automated early bone-loss detection in dental X-rays for timely periodontal care

  A clinician-facing AI tool helps identify subtle bone loss patterns in dental X-rays that are invisible to the naked eye, aiming to enable earlier diagnosis and prevention of periodontitis in adults.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11391295

• Mechanisms of bone loss after a fracture

  A study at UC San Francisco will look at why bones elsewhere in the body lose mass after a fracture by analyzing blood to find biological clues.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11386666

• Systemic bone loss after fracture in humans

  This project tests how a fracture in people affects bone loss across the body over time, especially comparing younger and older adults.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11369808

• Blood PFAS levels and bone loss in older adults

  This project will look at whether common environmental chemicals called PFAS in blood are linked to bone thinning and higher fracture risk in older adults.

  NIH research University of Massachusetts Amherst · Hadley, United States · NIH-11324617

• Periodontitis and HIV therapy–related bone loss in people living with HIV

  A study exploring how HIV treatment–related immune changes can drive bone loss around the teeth in people with HIV, and how periodontitis may worsen this effect.

  NIH research Emory University · Atlanta, United States · NIH-11323448

• Monthly risedronate pill to protect bones after sleeve gastrectomy

  This will see if a once-monthly risedronate pill helps protect bone health for people who have had sleeve gastrectomy.

  NIH research Wake Forest University · Winston-Salem, United States · NIH-11322517

• 3D-printed bone implants to rebuild bone lost from gum disease

  A new 3D-printed bone implant is being developed to help people who have lost jaw bone around their teeth from chronic gum disease.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11318988

• How LSD1 controls bone loss in gum (periodontal) disease

  Researchers are testing whether changing LSD1 activity can stop or reduce the bone loss around teeth that happens with gum disease.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11317243

• Plant-based probiotic/prebiotic to help keep bones strong with age

  A plant-derived probiotic/prebiotic supplement is given to older women to see if it helps preserve or improve bone strength and bone density.

  NIH research Hebrew Rehabilitation Center for Aged · Boston, United States · NIH-11311271

• Does long-term poor sleep cause bone loss in later life?

  This project looks at whether ongoing poor sleep in middle-age and older adults can lead to weaker bones, using a long-term rat model that mimics human sleep loss.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11307590

• Phosphate and bone health in aging veterans

  Aims to understand how phosphate intake affects bone loss and fracture risk in aging veterans.

  NIH research Veterans Health Administration · Decatur, UNITED STATES · NIH-11305286

• Bone structure and strength after sleeve gastrectomy with risedronate

  This project compares the osteoporosis drug risedronate to a placebo to help protect bone structure and strength in people aged 40 and older having sleeve gastrectomy.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11305223

• Why HIV and its medicines can cause muscle weakness and bone loss as people age

  This project looks at how HIV infection and long-term HIV medicines may cause muscle wasting and bone loss in older adults living with HIV.

  NIH research Augusta University · Augusta, United States · NIH-11300263

• Helping bones heal in rheumatoid arthritis

  This project uses a bone-targeted gene therapy to turn off a protein that blocks bone growth, aiming to help people with rheumatoid arthritis rebuild bone.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11286838

• High-dose vitamin D for bone and muscle loss in older men on hormone therapy

  Older men on androgen-deprivation therapy for prostate cancer will receive higher-dose vitamin D to help protect their bones and muscles.

  NIH research University of Rochester · Rochester, United States · NIH-11237584

• How low polyamine production may cause bone loss in chronic kidney disease

  This project tests whether reduced polyamines (spermine/spermidine) help explain bone weakness in people with chronic kidney disease.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11234288

• Targeting IgSF11 to prevent inflammatory bone loss

  This work looks at whether blocking a cell-surface protein called IgSF11 and its effects on cell metabolism can help people with inflammatory bone loss such as that seen in arthritis.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11232311

• Protecting bones after spinal cord injury with Wnt-targeted therapy and exercise

  This project combines a Wnt-targeting approach with exercise to help people with spinal cord injury preserve or rebuild bone.

  NIH research Rlr VA Medical Center · Indianapolis, United States · NIH-11222643

• How beta blocker medicines might protect bone after menopause

  This research looks at whether certain beta blocker medicines can help protect bone density in women after menopause.

  NIH research Mainehealth · Portland, United States · NIH-11189800

• Cadmium exposure and bone health in older adults

  This project looks at whether long-term cadmium exposure is linked to bone loss and fractures in older men and women.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11184369

• The link between urine cadmium levels and bone health in older adults

  This study is looking at how cadmium in urine might affect bone health and increase the risk of fractures in older adults, and it will track participants over 20 years to see how their bones change over time.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11182199

• Resistance exercise plus osteoporosis medication to protect bones during weight loss in older adults

  This project looks at whether strength-focused exercise combined with a common osteoporosis drug helps older adults keep bone density while losing weight.

  NIH research Wake Forest University · Winston-Salem, United States · NIH-11179404

• Bone loss after starting HIV treatment — the gut and microbiome

  This project looks at whether gut damage and changes in the gut microbiome cause bone loss in adults living with HIV who start antiretroviral therapy.

  NIH research Emory University · Atlanta, United States · NIH-11177753

• Investigating how nerve signaling affects bone loss after spinal cord injury

  This study is looking at how spinal cord injuries can lead to bone loss and is testing how certain nerve signals might affect this process, with the hope of finding new ways to help people with spinal cord injuries keep their bones healthy.

  NIH research Texas A&m University Health Science Ctr · College Station, United States · NIH-11164979

• Preventing bone loss after spinal cord injury with denosumab followed by zoledronic acid

  This project will test whether giving denosumab first and then zoledronic acid can help prevent rapid bone loss in people who recently had a spinal cord injury.

  NIH research Northwestern University · Chicago, United States · NIH-11158585

• How HIV and its treatment affect bone and tooth health

  This study is looking at how HIV and the medications used to treat it can affect bone health in the jaw, which is important for keeping your teeth healthy, and it's aimed at helping people living with HIV understand and improve their oral health.

  NIH research Emory University · Atlanta, United States · NIH-11144466

• Investigating the link between PFAS exposure and bone health in older adults

  This study is looking at how certain chemicals called PFAS might affect bone health and increase the risk of fractures in older adults, and it will follow a diverse group of people for up to 20 years to see how these chemicals impact their bones over time.

  NIH research University of Massachusetts Amherst · Hadley, United States · NIH-11142526

• Understanding how LSD1 affects bone loss in periodontal disease

  This study is looking at how a special enzyme called LSD1 affects bone loss from gum disease, using mice to learn more about how it works, and the goal is to find new ways to help people with periodontal disease keep their bones healthy.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11139273

• DMPA contraceptive shot, bone loss, and lead exposure in young women

  This project will see if young women who use the DMPA injectable contraceptive have higher blood lead levels because bone loss can release lead stored in bones.

  NIH research Michigan State University · East Lansing, United States · NIH-11127742

• How bacteria affect bone loss in periodontal disease

  This study is looking at how certain bacteria that cause gum disease affect bone cells in your jaw, which can lead to tooth loss, and it aims to find new ways to help people who aren't getting better with current treatments.

  NIH research Augusta University · Augusta, United States · NIH-11119127

• Understanding Bone Weakening After a Fracture

  This project looks at how a broken arm might affect bone strength throughout the body in both younger and older adults.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11099880

Related topics

Quick answers

How many Bone Loss clinical trials are recruiting right now?

21, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 23 countries. The most sites are in United States (5 trials), Egypt (4 trials), France (3 trials), Germany (2 trials), China (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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