Comparing high-resolution and pQCT scans to view bone and muscle structure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants with osteoporosis risk or related conditions (for example rheumatoid arthritis, spondyloarthritis, chronic kidney disease, endocrinopathies, sarcopenia, obesity, anorexia, constitutional thinness, or Parkinson's disease) and a control group will undergo imaging with HR-pQCT (XtremeCT), pQCT (XCT 3000) and DXA. The study compares cortical porosity, trabecular volume and other microarchitectural measures between pathological groups and age-matched controls to distinguish disease-related changes from normal aging. Imaging data will be collected at a single center (CHU Saint-Etienne) and analyzed to characterize differences across conditions. Results aim to clarify which imaging modality best detects microstructural changes that relate to bone fragility.

Why it matters

Who can join: the full rules

Inclusion Criteria:

For the patients:

Women or men treated at the Saint-Etienne University Hospital and presenting an osteoporotic risk with one of the following associated pathologies:

* Osteoporosis defined by: History of a documented brittle bone fracture
* Bone fragility: Patient with indication for bone densitometry but no history of fracture
* Inflammatory joint disease:

  * Rheumatoid arthritis
  * Spondyloarthritis
* Chronic kidney disease
* Endocrinopathies:

  * Primary hyperparathyroidism
  * Constitutional thinness
  * Anorexia nervosa
  * Obesity (BMI \>30)
  * Sarcopenia
* Neuropathies - Parkinson's disease

For the controls:

Acute episode of spinal or radiculalgia (less than one month old) with corticosteroid treatment of less than 1 month Signature of written consent

Exclusion Criteria:

* No sign written consent

For the controls:

* Medications inducing bone loss:
* anti-aromasin or GnRH agonist for at least 6 months,
* corticosteroids (dose ≥ 5 mg/d for 6 months)
* anti-epileptic drugs: carbamazepine, phenobarbital, phenytoin, primidone, valproic acid for at least 6 months)
* History of fracture due to bone fragility
* Taking bone-targeting medication (biphosphonate, teriparatide, strontium ranelate)

Where it's running

• Chu Saint Etienne
  Saint-Etienne, France Recruiting

Study contacts

• Principal investigator: Hubert MAROTTE, PhD — Centre Hospitalier Universitaire de Saint Etienne
• Study coordinator: Hubert MAROTTE, PhD
• Email: hubert.marotte@chu-st-etienne.fr
• Phone: (0)477127643

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.