Understanding how LSD1 affects bone loss in periodontal disease
Official title: The role of LSD1 in regulating periodontal induced bone loss
Funded at University of Minnesota · NIH-11139273 · Data updated 2026-11-12
This study is looking at how a special enzyme called LSD1 affects bone loss from gum disease, using mice to learn more about how it works, and the goal is to find new ways to help people with periodontal disease keep their bones healthy.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | April 8, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $236,756 |
| NIH project number | 1R21DE034067-01A1 |
| Project ID | NIH-11139273 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from periodontal disease, particularly those experiencing significant bone loss.
✕Less likely to help
Patients without periodontal disease or those whose bone loss is unrelated to inflammatory processes may not benefit from this research.
What this research studies
This research investigates the role of a specific enzyme, LSD1, in the regulation of bone loss caused by periodontal disease. By studying genetically modified mice, the researchers aim to uncover how LSD1 influences the activity of osteoclasts, the cells responsible for bone resorption. The project utilizes advanced techniques like RNA sequencing to analyze gene expression changes in these cells, which could lead to new insights into treating bone loss associated with inflammation. Patients with periodontal disease may benefit from findings that could lead to targeted therapies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce bone loss in patients with periodontal disease.
How similar studies have gone: Previous studies have shown promising results in understanding the molecular mechanisms of bone loss, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Mansky, Kim Carpenter — University of Minnesota
- Study coordinator: Mansky, Kim Carpenter
Related research
Other NIH-funded projects on the same topics.
-
How HIV and HIV meds affect jaw bone and teeth
This project looks at how HIV, its treatment, and immune changes may cause jawbone and tooth loss in people living with HIV.
-
Periodontitis and HIV treatment–related bone loss in the jaw and teeth
This project studies how HIV and its treatment affect jawbone and tooth loss in people living with HIV, aiming to understand and reduce bone damage around teeth.
-
Molecular clues to bone loss from disuse
This project looks for genes that influence bone loss when people or animals don’t move much, like during bed rest or spaceflight.
-
Oral-Gut–Bone Links in Periodontitis and Bone Loss
This research explores how gum disease could affect bone health by studying the connection between the mouth, gut, and bones in adults.
-
Bone health restoration after spinal cord injury through Wnt signaling and exercise
Aims to find a long-term way to preserve and rebuild bone in people with spinal cord injury, especially veterans, by combining exercise and bone-building signals.
-
Urine cadmium and bone health in older adults
This project looks at whether long-term cadmium exposure, measured in urine, is linked to bone loss and fractures in older adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.