Understanding how LSD1 affects bone loss in periodontal disease
The role of LSD1 in regulating periodontal induced bone loss
This study is looking at how a special enzyme called LSD1 affects bone loss from gum disease, using mice to learn more about how it works, and the goal is to find new ways to help people with periodontal disease keep their bones healthy.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11139273 on NIH RePORTER |
What this research studies
This research investigates the role of a specific enzyme, LSD1, in the regulation of bone loss caused by periodontal disease. By studying genetically modified mice, the researchers aim to uncover how LSD1 influences the activity of osteoclasts, the cells responsible for bone resorption. The project utilizes advanced techniques like RNA sequencing to analyze gene expression changes in these cells, which could lead to new insights into treating bone loss associated with inflammation. Patients with periodontal disease may benefit from findings that could lead to targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from periodontal disease, particularly those experiencing significant bone loss.
Not a fit: Patients without periodontal disease or those whose bone loss is unrelated to inflammatory processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce bone loss in patients with periodontal disease.
How similar studies have performed: Previous studies have shown promising results in understanding the molecular mechanisms of bone loss, suggesting that this approach could yield valuable insights.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Mansky, Kim Carpenter — University of Minnesota
- Study coordinator: Mansky, Kim Carpenter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.