Mechanisms of bone loss after a fracture
Official title: Mechanisms of systemic bone loss following fracture
Funded at University of California, San Francisco · NIH-11386666 · Data updated 2026-11-12
A study at UC San Francisco will look at why bones elsewhere in the body lose mass after a fracture by analyzing blood to find biological clues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 5, 2026 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $448,563 |
| NIH project number | 1R01AR087742-01 |
| Project ID | NIH-11386666 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with acute fractures (e.g., humerus fracture) who are enrolled in the parent longitudinal study at UCSF.
✕Less likely to help
Patients not experiencing systemic bone loss after fracture or not participating in blood collection may not benefit from this study.
What this research studies
Patients with a fracture may experience bone loss elsewhere in the body. This ancillary study will collect additional blood samples at multiple times after injury and use advanced genomic, protein, and metabolite analyses to understand the systemic processes affecting bone health. By examining circulating immune cells and biomarkers, researchers hope to map how injury-related inflammation and other biological signals contribute to future fracture risk. The goal is to identify potential pathways that could be targeted to prevent additional bone loss after a fracture.
Why it matters
Potential benefit: If successful, the findings could lead to new ways to protect bone health after injury and reduce future fracture risk.
How similar studies have gone: Previous research suggests systemic bone loss after fracture is real, but this study uses a comprehensive multimodal blood analysis that is relatively novel in this context.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Kazakia, Galateia J — University of California, San Francisco
- Study coordinator: Kazakia, Galateia J
Related research
Other NIH-funded projects on the same topics.
-
Urine cadmium and bone health in older adults
This project looks at whether long-term cadmium exposure, measured in urine, is linked to bone loss and fractures in older adults.
-
Systemic bone loss after fracture in humans
This project tests how a fracture in people affects bone loss across the body over time, especially comparing younger and older adults.
-
Blood PFAS levels and bone loss in older adults
This project will look at whether common environmental chemicals called PFAS in blood are linked to bone thinning and higher fracture risk in older adults.
-
Cadmium exposure and bone health in older adults
This project looks at whether long-term cadmium exposure is linked to bone loss and fractures in older men and women.
-
The link between urine cadmium levels and bone health in older adults
This study is looking at how cadmium in urine might affect bone health and increase the risk of fractures in older adults, and it will track participants over 20 years to see how their bones change over time.
-
Investigating the link between PFAS exposure and bone health in older adults
This study is looking at how certain chemicals called PFAS might affect bone health and increase the risk of fractures in older adults, and it will follow a diverse group of people for up to 20 years to see how these chemicals impact their bones over time.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.