Systemic bone loss after fracture in humans
Official title: Systemic Bone Loss Following Fracture in Humans
Funded at University of California, San Francisco · NIH-11369808 · Data updated 2026-11-12
This project tests how a fracture in people affects bone loss across the body over time, especially comparing younger and older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 30, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $807,776 |
| NIH project number | 5R01AG078347-04 |
| Project ID | NIH-11369808 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults aged 20-40 and 60-80 who have recently sustained a humerus fracture and are willing to undergo imaging studies.
✕Less likely to help
People without a recent humerus fracture or those unable to complete imaging may not benefit from this study.
What this research studies
The study will track people who recently had a humerus fracture using standard clinical imaging and advanced high-resolution scans to map how bone density changes systemically. It aims to chart how long any bone loss lasts, whether trabecular bone is more affected than cortical bone, and how recovery differs between younger and older adults. Researchers will compare time courses of bone mineral density at multiple sites, including the spine and arms, to understand systemic bone loss after fracture. The work builds on animal data and seeks to translate findings to human patients who have suffered fractures.
Why it matters
Potential benefit: If successful, the study could clarify how long patients remain at higher fracture risk after an injury and inform targeted prevention or treatment strategies.
How similar studies have gone: Preclinical studies in animals suggest a systemic bone loss after fracture; this trial extends that work to humans to confirm applicability.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Kazakia, Galateia J — University of California, San Francisco
- Study coordinator: Kazakia, Galateia J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.