Monitoring menopausal symptoms in women with gynecological cancer after ovary removal

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on women aged 18-55 with gynecological malignancies who have undergone bilateral ovariectomy. It aims to monitor changes in menopausal symptoms and bone health over time, particularly the effects of platinum-based chemotherapy on these symptoms and bone loss. The study seeks to identify the optimal timing and effective regimens for menopausal hormone therapy in this unique patient population, providing guidance for osteoporosis screening and prevention strategies. By understanding these dynamics, the study aims to improve the quality of life for women facing early menopause due to cancer treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Premenopausal women with gynecological malignancies aged 18-55 years old;

  * Tumor types include endometrial cancer, cervical cancer, epithelial ovarian cancer;

    * All patients received standard stage operation and treatment;

      * Patients with bilateral ovaries resection; ⑤Voluntarily participate in this study, willing to sign informed consent, and have long-term follow-up conditions.

Exclusion Criteria:

* Menopause (women over 40 years of age stop menstruation for 12 months, excluding pregnancy and other diseases that may cause amenorrhea can be clinically diagnosed as menopause); Or AMH \< 0.2ng/ml (China Menopause Management and Menopause Hormone Therapy Guidelines 2023 edition); Or FSH\> 40 mIU/ml after two checks within one month;

  * Other tumors were combined within 2 years and were still in radiotherapy, chemotherapy or hormone therapy;

    * Diagnosis of immunodeficiency disease or active hepatitis B, C, active tuberculosis; ④Serious organic diseases of the organs, etc., can not cooperate with the study follow-up; ⑤Long-term use of hormonal drugs for rheumatic system diseases, such as glucocorticoids;

      * Patients who have previously received pelvic or abdominal radiotherapy; ⑦ ECOG score ≥3 points; ⑧The patient did not sign informed consent or was unwilling to accept follow-up interviews.

Where it's running

• Anhui Provincal Hospital
  Hefei, Anhui, China Recruiting

Study contacts

• Study coordinator: Ying Zhou, MD
• Email: caddiezy@ustc.edu.cn
• Phone: +8613865901025

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.