Understanding induced membrane properties in bone reconstruction
Official title: Induced Membrane Properties in Children and Adults
Run by Centre Hospitalier Universitaire, Amiens · NCT04246944 · Data updated 2026-11-12
This study is testing how special membranes formed during a bone reconstruction technique can help improve healing in both children and adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 9 Months to 60 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Centre Hospitalier Universitaire, Amiens Academic / other |
| Locations | 1 site (Amiens) |
| Status | Recruiting |
| Started | May 23, 2019 |
| Main results expected | January 2030 |
| Study ends | January 2030 |
| Registry record updated | June 8, 2025 |
| Trial ID | NCT04246944 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients aged 9 months to 60 years who are treated for bone critical sized defects using the induced membrane reconstruction technique.
✕Probably not a fit
Patients who are managed by other reconstruction techniques or those who are pregnant, nursing, or under guardianship may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the properties of induced membranes formed during the Masquelet technique for bone reconstruction in critical sized defects. It aims to characterize the angiogenesis and osteogenic properties of these membranes in both children and adults. By analyzing the induced membranes, the study seeks to enhance the understanding of their role in bone healing and improve surgical outcomes. Participants will include patients treated at CHU Amiens-Picardie who are undergoing this specific reconstruction technique.
Why it matters
Potential benefit: If successful, this study could lead to improved techniques for bone healing and reconstruction in patients with critical sized defects.
How similar studies have gone: While the Masquelet technique has been used in practice, the specific characterization of induced membrane properties is a novel approach that has not been extensively studied.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients treated at CHU Amiens-Picardie for bone critical sized defect treated using the induced membrane reconstruction technique. * patients from 9 months to 60 years old Exclusion Criteria: * Patients managed by another reconstruction technique for critical sized defect * Patients under guardianship, curators or deprived of liberty. * Pregnant and nursing women. * Patients who refused to participate in the study and to sign informed consent.
Where it's running
-
CHU Amiens
Amiens, France Recruiting
Study contacts
- Principal investigator: Céline Klein, MD — CHU Amiens
- Study coordinator: Céline Klein, MD
- Email: klein.celine@chu-amiens.fr
- Phone: (33)322087571
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.