Clinical trial Recruiting at 1 site Interventional Ages 9 Months to 60

Understanding induced membrane properties in bone reconstruction

Official title: Induced Membrane Properties in Children and Adults

Run by Centre Hospitalier Universitaire, Amiens · NCT04246944 · Data updated 2026-11-12

This study is testing how special membranes formed during a bone reconstruction technique can help improve healing in both children and adults.

Quick facts

Study typeInterventional
Ages9 Months to 60 Years
SexAll
Enrollment50 (estimated)
SponsorCentre Hospitalier Universitaire, Amiens
Academic / other
Locations1 site (Amiens)
StatusRecruiting
StartedMay 23, 2019
Main results expectedJanuary 2030
Study endsJanuary 2030
Registry record updatedJune 8, 2025
Trial IDNCT04246944 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are patients aged 9 months to 60 years who are treated for bone critical sized defects using the induced membrane reconstruction technique.

Probably not a fit

Patients who are managed by other reconstruction techniques or those who are pregnant, nursing, or under guardianship may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the properties of induced membranes formed during the Masquelet technique for bone reconstruction in critical sized defects. It aims to characterize the angiogenesis and osteogenic properties of these membranes in both children and adults. By analyzing the induced membranes, the study seeks to enhance the understanding of their role in bone healing and improve surgical outcomes. Participants will include patients treated at CHU Amiens-Picardie who are undergoing this specific reconstruction technique.

Why it matters

Potential benefit: If successful, this study could lead to improved techniques for bone healing and reconstruction in patients with critical sized defects.

How similar studies have gone: While the Masquelet technique has been used in practice, the specific characterization of induced membrane properties is a novel approach that has not been extensively studied.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* All patients treated at CHU Amiens-Picardie for bone critical sized defect treated using the induced membrane reconstruction technique.
* patients from 9 months to 60 years old

Exclusion Criteria:

* Patients managed by another reconstruction technique for critical sized defect
* Patients under guardianship, curators or deprived of liberty.
* Pregnant and nursing women.
* Patients who refused to participate in the study and to sign informed consent.

Where it's running

  • CHU Amiens
    Amiens, France
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.