Urine cadmium and bone health in older adults
Urine cadmium and risk of fracture and bone loss
['FUNDING_R01'] · STATE UNIVERSITY NEW YORK STONY BROOK · NIH-11420047
This project looks at whether long-term cadmium exposure, measured in urine, is linked to bone loss and fractures in older adults.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY NEW YORK STONY BROOK (nih funded) |
| Locations | 1 site (STONY BROOK, UNITED STATES) |
| Trial ID | NIH-11420047 on ClinicalTrials.gov |
What this research studies
Researchers will use urine samples and health records from two large groups of older adults who have been followed for up to 20 years to compare cadmium levels with bone scans and fracture histories. They will measure urinary cadmium as a marker of long-term exposure and track changes in bone mineral density and recorded fractures over time. The team will account for other factors like age, smoking, diet, and kidney function so people like you can understand whether environmental cadmium might be contributing to weaker bones.
Who could benefit from this research
Good fit: The research focuses on older adults (generally age 65 and up), especially those with long-term health records and biospecimens who can help link urine cadmium to bone outcomes.
Not a fit: Younger adults, people without available long-term health data or urine samples, and those whose bone loss is clearly caused by non-environmental factors may not see direct benefit.
Why it matters
Potential benefit: If successful, this work could reveal cadmium as a preventable environmental risk for bone loss and fractures, guiding screening, dietary advice, or public health reductions in exposure.
How similar studies have performed: Previous cross-sectional studies have linked cadmium to lower bone density and fractures, but large long-term prospective analyses like this are relatively novel.
Where this research is happening
STONY BROOK, UNITED STATES
- STATE UNIVERSITY NEW YORK STONY BROOK — STONY BROOK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MELIKER, JAYMIE R — STATE UNIVERSITY NEW YORK STONY BROOK
- Study coordinator: MELIKER, JAYMIE R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.