Evaluating bone density and vascular calcifications after kidney transplant
Official title: Evolution of Bone Density, Bone Micro-architecture and Vascular Calcifications in Patients After Kidney Transplantation
Run by University of Liege · NCT04713774 · Data updated 2026-11-12
This study is looking at how bone and blood vessel health change over time in people who have recently had a kidney transplant to help improve their recovery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | University of Liege Academic / other |
| Drugs / interventions | denosumab |
| Locations | 1 site (Liège) |
| Status | Recruiting |
| Started | September 1, 2020 |
| Main results expected | December 12, 2025 |
| Study ends | December 13, 2026 |
| Registry record updated | December 18, 2024 |
| Trial ID | NCT04713774 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who have received a kidney transplant within the last three months.
✕Probably not a fit
Patients who have received bisphosphonate treatment or other bone-active medications in the last three months, as well as those undergoing multiple organ transplants, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study assesses bone architecture and vascular calcifications in recent kidney transplant patients using high-resolution peripheral quantitative CT and DEXA scans. It aims to understand the evolution of bone and vascular health over time by analyzing nephrological clinical parameters and biological markers related to mineral metabolism. The study seeks to establish relationships between bone mass, muscle mass, and the presence of vascular calcifications, which are critical for improving patient outcomes post-transplant.
Why it matters
Potential benefit: If successful, this study could lead to better prevention and management of bone and vascular complications in kidney transplant patients.
How similar studies have gone: While the specific approach of this study may be novel, there is existing literature on the complications of bone and vascular health in kidney transplant patients, indicating a need for further exploration.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * At least 18 years old * Recent kidney transplant patients (\<3 months) * Medical history available * Biological parameters of the past year available Exclusion Criteria: * Treatment with bisphosphonate, RANKL inhibitor or SERM with bone action in the last 3 months before the transplant * Multiple organ transplant patients
Where it's running
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Centre Hospitalier Universitaire de Liège
Liège, Belgium Recruiting
Study contacts
- Principal investigator: Antoine Bouquegneau — University of Liege
- Study coordinator: Antoine Bouquegneau
- Email: antoine.bouquegneau@gmail.com
- Phone: +32473353321
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How Propofol and Sevoflurane Affect miRNA in Living Kidney Donors
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How kidney transplant patients feel about using artificial intelligence in medicine
This international survey asks adults who have had a kidney transplant how they feel about AI tools that predict graft loss and what it might mean for their daily care.
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Personalized therapeutic stories for children after kidney transplant.
We will test whether clinician-supervised AI can create age-appropriate, personalized therapeutic stories for children aged 5–12 who have received a kidney transplant and their families.
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Treating blood vessel problems after a kidney transplant
This effort will try catheter-based angioplasty and advanced imaging to see if they help kidney transplant recipients with graft dysfunction or stubborn high blood pressure from possible transplant blood‑vessel problems.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.