Exploring the role of induced membranes in bone reconstruction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the Masquelet technique, a two-stage surgical approach used to treat severe bone fractures by creating a biological membrane that enhances bone healing. The first stage involves the implantation of surgical cement to induce a membrane, while the second stage involves the implantation of an autologous bone graft. The study aims to understand the role of this induced membrane in cases where bone consolidation fails, providing insights into improving surgical outcomes. Data will be collected through blood samples, biological samples, surgical waste, and radiological examinations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Patient with traumatic bone loss
* Patient eligible for the induced membrane technique

Exclusion Criteria:

* Patients with post-tumor bone loss
* Patients who are immunocompromised or under immunosuppressive treatment
* Patients with chronic inflammatory disease (diabetes, inflammatory bowel disease)
* Patients with collagenosis
* Patient with a contraindication to sampling
* Pregnant or breastfeeding women

Where it's running

• Hôpital d'Instruction des Armées Percy
  Clamart, France Recruiting
• Hôpital d'Instruction des Armées Bégin
  Saint-Mandé, France Recruiting

Study contacts

• Study coordinator: Marjorie DURAND, PhD
• Email: marjorie1.durand@intradef.gouv.fr
• Phone: 178651146

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.