Comparing two methods for bone ridge augmentation before dental implants
Official title: Lateral Ridge Augmentation Using Allograft Bone Particles Hydrated With or Without Recombinant Human Platelet-Derived Growth Factor: A Clinical and Histological Randomized Controlled Trial
Run by University of Alabama at Birmingham · NCT04954664 · Data updated 2026-11-12
This study is testing two different ways to help patients get enough bone for dental implants to see which method works better for healing.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 44 (estimated) |
| Sponsor | University of Alabama at Birmingham Academic / other |
| Locations | 1 site (Birmingham, Alabama) |
| Status | Recruiting |
| Started | August 11, 2021 |
| Main results expected | December 2026 |
| Study ends | December 2027 |
| Registry record updated | December 29, 2025 |
| Trial ID | NCT04954664 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are English-speaking adults over 18 with insufficient alveolar ridge width for dental implants.
✕Probably not a fit
Patients who are non-English speaking, under 18, smokers, or have systemic conditions affecting healing may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to compare the effectiveness of two techniques for increasing ridge dimensions in patients preparing for dental implants. One technique uses bone particulate allograft hydrated with recombinant human platelet-derived growth factor (rhPDGF), while the other uses the same allograft hydrated with saline. The study is prospective, randomized, and examiner-only-masked, involving bone core biopsies and clinical measurements at two time points to assess healing differences. Cone beam computed tomography scans will also be utilized to monitor bone health before and after the augmentation.
Why it matters
Potential benefit: If successful, this study could enhance the success rate of dental implants by improving bone ridge dimensions.
How similar studies have gone: Previous studies have shown promising results with similar approaches using growth factors in bone augmentation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * English speaking * At least 18 years old * Must be a patient of the UAB Dental School * Able to read and understand informed consent document * Need for implants to replace missing tooth or teeth in at least one quadrant of the mouth. * Insufficient alveolar ridge width for endosseous implant placement defined as 5mm or less as determined by bone sounding and cone beam computed tomography (CBCT) scan. Exclusion Criteria: * Non-English speaking * Less than 18 years old * Smokers/tobacco users (\>10 cigarettes/day) * Patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing * Patient is a poor compliance risk (i.e., poor oral hygiene, history of alcohol or drug abuse) * Vertical loss of bone at edentulous ridge.
Where it's running
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Unversity of Alabama at Birmingham, School of Dentistry
Birmingham, Alabama, United States Recruiting
Study contacts
- Study coordinator: Hussein Basma, DDS, MS
- Email: basma86@uab.edu
- Phone: 205-934-2888
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.