Understanding Bone Weakening After a Fracture
Official title: Systemic Bone Loss Following Fracture in Humans
Funded at University of California, San Francisco · NIH-11099880 · Data updated 2026-11-12
This project looks at how a broken arm might affect bone strength throughout the body in both younger and older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 30, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $862,577 |
| NIH project number | 5R01AG078347-03 |
| Project ID | NIH-11099880 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this work are human patients between 20-40 years old or 60-80 years old who have recently experienced a humerus fracture.
✕Less likely to help
Patients who have not experienced a recent humerus fracture or who fall outside the specified age ranges may not directly benefit from this particular research.
What this research studies
When you break a bone, it might not just be that one spot that's affected; your entire skeleton could experience some bone loss. We want to understand how much bone is lost and how long it takes for bones to recover after a humerus (upper arm) fracture. We will use advanced imaging techniques to see these changes in bone density and structure. Our goal is to find out if older individuals experience more severe or longer-lasting bone loss compared to younger people after a fracture.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent future fractures by understanding and addressing widespread bone weakening after an initial break.
How similar studies have gone: Previous studies in mice have shown a systemic bone loss response after fracture, but this phenomenon has not yet been thoroughly investigated in humans.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Kazakia, Galateia J — University of California, San Francisco
- Study coordinator: Kazakia, Galateia J
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The link between urine cadmium levels and bone health in older adults
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.