Improving brain protection during aortic arch surgery
Official title: Cerebral Protection in Aortic Arch Surgery
Run by Barts & The London NHS Trust · NCT04966247 · Data updated 2026-11-12
This study is testing a new way to monitor brain health during aortic arch surgery to see if it can help prevent brain problems after the operation.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Barts & The London NHS Trust Academic / other |
| Locations | 1 site (London) |
| Status | Recruiting |
| Started | July 19, 2023 |
| Main results expected | October 19, 2026 |
| Study ends | October 19, 2026 |
| Registry record updated | September 8, 2026 |
| Trial ID | NCT04966247 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and over who are scheduled for aortic arch surgery and can provide informed consent.
✕Probably not a fit
Patients who may not benefit from this study include those with preoperative neurological dysfunction or those who cannot provide informed consent.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on patients undergoing aortic arch surgery, a complex procedure for treating serious aortic conditions. It aims to evaluate the effectiveness of microdialysis as a cerebral monitoring technique to detect early cerebral ischaemia, which current methods like EEG and cerebral oximetry fail to do adequately. By analyzing serum markers such as S100B protein and neuron-specific enolase, the study seeks to improve patient outcomes and reduce the risk of neurological complications associated with the surgery. The findings could lead to enhanced strategies for cerebral protection during these high-risk procedures.
Why it matters
Potential benefit: If successful, this study could significantly reduce the incidence of neurological complications and improve the quality of life for patients undergoing aortic arch surgery.
How similar studies have gone: While there have been advancements in cerebral protection strategies, this approach using microdialysis is relatively novel and has not been extensively tested in this specific context.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing aortic arch surgery * Patients aged 18 and over * Patients who are able to provide informed consent Exclusion Criteria: * Patients with intraoperative death * Patients with preoperative neurological dysfunction * Patients who are not able to provide informed consent (language barrier, unconscious, unable to understand, retain and process information)
Where it's running
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St Bartholomew's Hospital
London, United Kingdom Recruiting
Study contacts
- Principal investigator: Aung Ye Oo, MD, FRCS-CTh — Queen Mary University London
- Study coordinator: Myat Soe Thet, MD, MSc
- Email: myatsoe.thet@nhs.net
- Phone: +44 20 7377 7000
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.