Improving brain protection during aortic arch surgery
Cerebral Protection in Aortic Arch Surgery
This study is testing a new way to monitor brain health during aortic arch surgery to see if it can help prevent brain problems after the operation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Barts & The London NHS Trust Academic / other |
| Locations | 1 site (London) |
| Trial ID | NCT04966247 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients undergoing aortic arch surgery, a complex procedure for treating serious aortic conditions. It aims to evaluate the effectiveness of microdialysis as a cerebral monitoring technique to detect early cerebral ischaemia, which current methods like EEG and cerebral oximetry fail to do adequately. By analyzing serum markers such as S100B protein and neuron-specific enolase, the study seeks to improve patient outcomes and reduce the risk of neurological complications associated with the surgery. The findings could lead to enhanced strategies for cerebral protection during these high-risk procedures.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and over who are scheduled for aortic arch surgery and can provide informed consent.
Not a fit: Patients who may not benefit from this study include those with preoperative neurological dysfunction or those who cannot provide informed consent.
Why it matters
Potential benefit: If successful, this study could significantly reduce the incidence of neurological complications and improve the quality of life for patients undergoing aortic arch surgery.
How similar studies have performed: While there have been advancements in cerebral protection strategies, this approach using microdialysis is relatively novel and has not been extensively tested in this specific context.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing aortic arch surgery * Patients aged 18 and over * Patients who are able to provide informed consent Exclusion Criteria: * Patients with intraoperative death * Patients with preoperative neurological dysfunction * Patients who are not able to provide informed consent (language barrier, unconscious, unable to understand, retain and process information)
Where this trial is running
London
- St Bartholomew's Hospital — London, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Aung Ye Oo, MD, FRCS-CTh — Queen Mary University London
- Study coordinator: Myat Soe Thet, MD, MSc
- Email: myatsoe.thet@nhs.net
- Phone: +44 20 7377 7000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.