Condition

Aortic Dissection clinical trials and research

• 24Clinical trials
• 16NIH research projects
• 21Countries

Newest Aortic Dissection clinical trials

All recruiting trials (24)

• Pregnancy-Related Aortic Dissection in China

  This study looks at cases of aortic dissection that occur during pregnancy or shortly after, to understand outcomes for mothers and babies.

  Recruiting at 4 sites DeltaHealth Hospital · Shanghai · Shanghai, Shanghai Municipality and 3 other locations · NCT07672210

• Ketorolac to improve outcomes and prognosis in Stanford Type A aortic dissection

  This trial will test whether giving ketorolac around emergency surgery helps adults (18–65) with Stanford Type A aortic dissection recover better and have fewer complications over 90 days.

  Recruiting Phase 3 The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing, Jiangsu · NCT06968806

• WeFlow-EndoPatch for Distal Aortic Tear Repair in Chronic Dissection

  This study tests whether the WeFlow-EndoPatch Aortic Endovascular Patch can safely and effectively seal distal tears in chronic aortic dissection compared with standard treatment.

  Recruiting Hangzhou Endonom Medtech Co., Ltd. · Beijing, Beijing Municipality · NCT06945809

• Aortic arch single-branch covered stent graft for treating aortic dissection

  This trial tests a single-branch covered stent graft in adults with Stanford Type B aortic dissection who need revascularization of the left subclavian artery.

  Recruiting Lifetech Scientific (Shenzhen) Co., Ltd. · Changsha · NCT06915545

• Multicenter study on acute type A aortic dissection

  This study is trying to learn more about patients with acute type A aortic dissection by looking at their health details, surgeries, and recovery to see what affects their outcomes.

  Recruiting Karolinska Institutet · Stockholm · NCT06862583

• Shape‑memory polymer to seal the false lumen and prevent aortic enlargement

  This trial will try a shape‑memory polymer implant to seal the false lumen and stop aortic growth in adults with type B dissection or treated type A dissection who need false lumen repair.

  Recruiting at 2 sites Shape Memory Medical, Inc. · Auckland and 1 other locations · NCT06550986

• Using sivelestat to protect lung function after heart surgery

  This study is testing if giving sivelestat to patients having emergency heart surgery can help protect their lungs and improve recovery by reducing serious complications.

  Recruiting at 2 sites Nanjing Medical University · Beijing and 1 other locations · NCT06195267

• Identifying biomarkers for diagnosing aortic dissection in emergency patients

  This study is testing if certain blood markers can help doctors quickly diagnose aortic dissection in emergency patients.

  Recruiting Chinese University of Hong Kong · Shatin, NT · NCT06065306

• Comparing two surgical methods for treating acute aortic dissection

  This study is testing two different surgical methods for treating a serious type of aortic dissection to see which one helps patients recover better and have fewer complications.

  Recruiting Chinese University of Hong Kong · Hong Kong, Hong Kong · NCT06044259

• Prognosis prediction for patients with cardiovascular and cerebrovascular diseases using multi-omics

  This study is trying to find out how different biological factors affect people with heart and brain blood vessel diseases to help doctors predict outcomes and personalize treatments for them.

  Recruiting First Affiliated Hospital Xi'an Jiaotong University · Xi'an, Shaanxi · NCT06001073

• Understanding Aortic Dissection in China

  This study is trying to learn more about aortic dissection by tracking patients over time to see how the condition affects them and what factors influence their recovery.

  Recruiting First Affiliated Hospital Xi'an Jiaotong University · Xi'an, Shaanxi · NCT05999188

• Evaluating TEVAR for uncomplicated aortic dissection

  This study is testing if adding a special procedure called TEVAR to standard treatment can help people with uncomplicated aortic dissection live longer and have better health outcomes.

  Recruiting at 19 sites University of Aarhus · Aalborg and 27 other locations · NCT05215587

• Improving brain protection during aortic arch surgery

  This study is testing a new way to monitor brain health during aortic arch surgery to see if it can help prevent brain problems after the operation.

  Recruiting Barts & The London NHS Trust · London · NCT04966247

• Creating a tool to improve CT imaging decisions for blunt trauma patients

  This study is testing a new tool to help doctors decide when CT scans are really needed for patients with blunt trauma to avoid unnecessary radiation and costs.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT04937868

• Evaluation of a new valved graft for heart surgery

  This study is testing a new heart valve graft in patients having heart surgery to see how well it works and if it's safe.

  Recruiting at 21 sites Abbott Medical Devices · Birmingham, Alabama and 24 other locations · NCT04754217

• New technique for repairing thoracic aortic conditions

  This study is testing a new method to repair certain serious aortic conditions in patients by using a special type of stent to see if it is safe and effective.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT04747626

• Endovascular repair for complex aortic conditions using modified grafts

  This study is testing a new type of graft to see if it can safely and effectively repair complex aortic problems in high-risk patients who can't have traditional surgery.

  Recruiting Beth Israel Deaconess Medical Center · Boston, Massachusetts · NCT04746677

• Evaluation of the NEXUS Aortic Arch Stent Graft System for treating aortic conditions

  This study is testing a new stent graft system to see if it can safely and effectively treat certain aortic problems in patients with specific conditions.

  Recruiting at 25 sites Endospan Ltd. · Birmingham, Alabama and 31 other locations · NCT04471909

• Precision medicine for heritable thoracic aortic disease

  This study is trying to learn more about genetic factors in people with heritable thoracic aortic disease to help doctors better predict risks and manage their care.

  Recruiting at 20 sites The University of Texas Health Science Center, Houston · Newport Beach, California and 19 other locations · NCT04005976

• Hemiarch versus extended arch repair for acute DeBakey type 1 aortic dissection

  This study will test whether an extended arch repair or the standard hemiarch repair leads to fewer deaths and fewer repeat operations in adults needing emergency surgery for acute DeBakey type 1 aortic dissection.

  Recruiting at 5 sites Ottawa Heart Institute Research Corporation · London, Ontario and 4 other locations · NCT03885635

• Identifying biomarkers for aortic aneurysm and dissection

  This study is trying to find specific markers in the blood that can help doctors diagnose and predict outcomes for people with aortic aneurysm and aortic dissection.

  Recruiting Beijing Institute of Heart, Lung and Blood Vessel Diseases · Beijing, Beijing Municipality · NCT03233087

• Project to improve cardiovascular health through biobanking

  This project is collecting blood samples and health information from people with heart diseases and healthy individuals to help researchers learn more about heart health and its genetic factors.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT02306200

• Endovascular repair for ascending aortic conditions

  This study is testing if a special stent can safely repair problems in the ascending aorta for patients with conditions like aortic dissection and pseudoaneurysms.

  Recruiting at 2 sites MemorialCare Health System · Long Beach, California and 2 other locations · NCT02201589

• Evaluating new endografts for treating complex aortic conditions

  This study is testing new types of stents for people with complicated aortic conditions to see if they are safe and effective compared to standard treatments.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT02043691

NIH-funded research (16)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Improving Outcomes in Vascular Disease for Aortic Dissection: Upfront TEVAR vs Surveillance

  A large US study will compare starting treatment with a repair procedure plus medicine to medicine alone with careful follow-up in people with uncomplicated type B aortic dissection.

  NIH research Duke University · Durham, United States · NIH-11605968

• Improving Outcomes in Aortic Dissection: Upfront TEVAR vs Surveillance (IMPROVE-AD) for Uncomplicated Type B Dissection

  A large, patient-friendly study will compare starting with medicine plus an upfront TEVAR procedure versus medicine with careful monitoring for people with uncomplicated type B aortic dissection.

  NIH research Duke University · Durham, United States · NIH-11605967

• IMPROVE-AD: Better outcomes for uncomplicated type B aortic dissection

  A large patient study in the US will compare starting with medical care plus upfront TEVAR versus medical care with monitoring alone to see which approach leads to better outcomes for people with uncomplicated type B aortic dissection.

  NIH research Duke University · Durham, United States · NIH-11393353

• Upfront TEVAR plus medical therapy vs lifelong monitoring for uncomplicated type B aortic dissection

  A large US study tests whether adding early TEVAR to standard medical care helps people with uncomplicated type B aortic dissection live better than medical care alone with ongoing monitoring.

  NIH research Duke University · Durham, United States · NIH-11393329

• Non-invasive 4D flow MRI to predict risk in aortic dissection

  A study using 4D flow MRI to help doctors predict which patients with aortic dissection are at higher long-term risk so they can tailor treatment.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11385397

• Early aortic stent plus medicine versus medicine with watchful waiting for uncomplicated type B aortic dissection

  This compares giving an early aortic stent graft plus medicines to using medicines with close follow-up for people with uncomplicated type B aortic dissection to find which approach leads to better outcomes.

  NIH research Duke University · Durham, United States · NIH-11381649

• Improving care for people with type B aortic dissection

  This study will compare immediate stent-graft repair plus medicines to medicines with watchful waiting for people with uncomplicated type B aortic dissection.

  NIH research Duke University · Durham, United States · NIH-11379246

• A new catheter to help endograft placement for acute aortic dissection

  A new, minimally invasive device is being tested to help doctors place endografts more safely in patients with acute aortic dissection.

  NIH research Cutcath LLC · Bloomfield Hills, UNITED STATES · NIH-11371187

• 4D flow MRI to predict outcomes in Type B aortic dissection

  A patient-centered look at how advanced 4D flow MRI can help predict who with Type B aortic dissection will have complications, guiding safer treatment decisions.

  NIH research Northwestern University · Chicago, United States · NIH-11292879

• Better treatment options for type B aortic dissection

  This project compares adding early minimally invasive aortic repair (TEVAR) to usual medical care versus medical care with watchful waiting for people with uncomplicated type B aortic dissection.

  NIH research Duke University · Durham, United States · NIH-11132820

• How aorta shape affects dissection risk and stability

  This project uses routine CT angiograms and new math to find patterns in aortic shape that help predict which type B aortic dissections are stable or likely to worsen.

  NIH research University of Chicago · Chicago, United States · NIH-11118801

• Understanding blood flow and outcomes in Type B aortic dissection using advanced MRI techniques

  This study is looking at how a special type of MRI can help doctors understand blood flow in patients with Type B aortic dissection, so they can better predict risks and improve treatment plans for those affected.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-11036408

• Improving outcomes for patients with aortic dissection

  This study is looking at two different ways to treat people with uncomplicated type B aortic dissection to see which one works better: one approach combines medication with a quick surgery, while the other relies on medication and careful monitoring, and we're inviting 1,100 participants from across the U.S. to help us

  NIH research Duke University · Durham, United States · NIH-11027406

• Identifying risks in patients with uncomplicated type B aortic dissection

  This study is looking at patients with uncomplicated type B aortic dissection to find out who might need earlier treatment instead of just standard care, so they can get the best help possible.

  NIH research Emory University · Atlanta, United States · NIH-10897983

• Improving treatment outcomes for patients with aortic dissection

  This study is looking at two different ways to treat patients with uncomplicated type B aortic dissection to see which works better: one group will get medicine plus a quick surgery to fix the problem, while the other group will just get medicine and regular check-ups. They're hoping to include 1,100 people from across

  NIH research Duke University · Durham, United States · NIH-10892225

• Understanding how aortic dissections change over time

  This study is looking at how to better understand and predict the stability of type B aortic dissections using advanced imaging techniques, so that doctors can provide more personalized care and help patients know their risk.

  NIH research University of Chicago · Chicago, United States · NIH-10862611

Related topics

Quick answers

How many Aortic Dissection clinical trials are recruiting right now?

24, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in China (9 trials), United States (9 trials), United Kingdom (3 trials), New Zealand (2 trials), Canada (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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