PAR2 role in abdominal aortic aneurysm development
Official title: The role of protease activated receptor 2 in the initiation and progression of abdominal aortic aneurysm
Funded at University of Cincinnati · NIH-11332797 · Data updated 2026-11-12
Researchers are studying how a specific receptor (PAR2) in blood vessels might contribute to the development and progression of abdominal aortic aneurysms, with potential pathways to new treatments for people with the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | May 15, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $703,198 |
| NIH project number | 5R01HL179626-02 |
| Project ID | NIH-11332797 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older who have or are at risk for abdominal aortic aneurysm, particularly those 65 and older.
✕Less likely to help
The study is more focused on mechanisms; individuals without AAA or at low risk may not directly benefit.
What this research studies
This project explores how the protease-activated receptor 2, a seven‑transmembrane receptor, may drive inflammation and vessel wall changes in abdominal aortic aneurysm. Using models of AAA and human tissue data, the study examines how PAR2 affects vascular cells and immune signals, aiming to identify mechanisms that could be targeted by new drugs. If successful, findings could point toward non-surgical options to slow or prevent aneurysm growth and rupture. The research involves detailed cellular analysis and animal or tissue-based experiments to connect PAR2 activity with aneurysm biology and patient-relevant outcomes.
Why it matters
Potential benefit: Could lead to new drug targets to treat or prevent abdominal aortic aneurysm and reduce risk of rupture.
How similar studies have gone: Previous work in related vascular disease models suggests PAR2 can influence vascular inflammation and remodeling, making this approach promising but still investigational.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Owens Iii, Albert Phillip — University of Cincinnati
- Study coordinator: Owens Iii, Albert Phillip
Related research
Other NIH-funded projects on the same topics.
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-
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A research team will study how genetic differences influence abdominal aortic aneurysm to help with earlier prevention and better treatment.
-
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A new nanoparticle treatment is being developed to slow or stop the growth of abdominal aortic aneurysms in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.