Platelets and abdominal aortic aneurysm growth
Official title: Platelets as Biosensors and Mediators of Aortic Aneurysm Growth
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11109654 · Data updated 2026-11-12
Looking at whether blocking a specific platelet receptor can help slow aneurysm growth in older adults with abdominal aortic aneurysms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $489,364 |
| NIH project number | 5R01HL158801-05 |
| Project ID | NIH-11109654 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are older adults (about 65 and older) who have an unruptured abdominal aortic aneurysm and can provide blood samples or attend visits at the study site.
✕Less likely to help
People without an abdominal aortic aneurysm, those with a ruptured aneurysm requiring emergency care, or patients whose aneurysm is unrelated to platelet activity are unlikely to benefit from this project.
What this research studies
Researchers will work with platelets taken from people with abdominal aortic aneurysms and expose them to blood-flow conditions that mimic aneurysms. They will study a newly identified receptor on the platelet surface that appears to make platelets overactive and release proteins linked to faster aneurysm growth. Lab tests will compare how blocking that receptor works versus aspirin and other antiplatelet approaches. The team will also look for platelet-derived proteins in blood that could act as biomarkers to tell who has a fast-growing aneurysm.
Why it matters
Potential benefit: If successful, this research could produce the first drug approach to slow aneurysm growth and blood tests to identify patients at high risk of rapid enlargement.
How similar studies have gone: Prior work suggests aspirin can partially slow aneurysm growth, but targeting the platelet olfactory receptor and using platelet proteins as biomarkers is a new and untested approach.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Cameron, Scott James — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Cameron, Scott James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.