Sexual differences in thoracic aortic aneurysm biology

Who could benefit from this research

What this research studies

This project looks at human thoracic aortic tissue to understand why men and women have different disease progress. Researchers will map where specific cells and molecules sit in the tissue and test how sex-related signals may drive changes in the aorta. They will use high-resolution spatial profiling to pinpoint cell types and pathways that differ by sex and relate these findings to how the aorta remodels and stiffens. The results could reveal targets to explain or treat these gender differences in TAAs. The work is centered on human tissue and aims to translate observations into better care for patients with TAAD.

Why it matters

Where this research is happening

• University of Michigan at Ann Arbor
  Ann Arbor, United States Active

Researchers

• Principal investigator: Mizrak, Dogukan — University of Michigan at Ann Arbor
• Study coordinator: Mizrak, Dogukan

Related research

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.