New Nanoparticle Treatment for Abdominal Aortic Aneurysm
Official title: Development of phospholipid-based nanotherapeutics for treating abdominal aortic aneurysm
Funded at University of Michigan at Ann Arbor · NIH-11090423 · Data updated 2026-11-12
This research explores a new way to deliver anti-inflammatory medicine using tiny particles to help patients with abdominal aortic aneurysms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | July 1, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $763,935 |
| NIH project number | 5R01HL165688-03 |
| Project ID | NIH-11090423 on NIH RePORTER |
Who could benefit from this research
✓Could help
This research is most relevant for adult patients aged 21 and older who have been diagnosed with a small abdominal aortic aneurysm that does not yet require surgical repair.
✕Less likely to help
Patients with large or symptomatic abdominal aortic aneurysms that already require immediate surgical intervention may not directly benefit from this specific approach.
What this research studies
Abdominal aortic aneurysm (AAA) is a serious condition where the main artery in your belly bulges, and it can be life-threatening if it ruptures. Currently, surgery is the only effective treatment for large aneurysms, but many smaller aneurysms grow over time and eventually need surgery. There isn't a good medicine right now to stop these smaller aneurysms from growing. This project aims to create a new medical treatment using special nanoparticles that can target the aneurysm directly. These nanoparticles would deliver anti-inflammatory agents to reduce swelling and improve the health of the artery wall, potentially preventing the aneurysm from getting bigger.
Why it matters
Potential benefit: If successful, this new treatment could offer a non-surgical option to slow or stop the growth of abdominal aortic aneurysms, reducing the risk of rupture for many patients.
How similar studies have gone: While previous anti-inflammatory drugs have not shown success in clinical trials for AAA, studies in animal models have shown that reducing inflammation can effectively slow aneurysm progression, and this project introduces a novel nanoparticle delivery strategy.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Guo, Yanhong — University of Michigan at Ann Arbor
- Study coordinator: Guo, Yanhong
Related research
Other NIH-funded projects on the same topics.
-
How the small regulator miR-146a affects abdominal aortic aneurysm
This project aims to see if boosting a natural genetic regulator called miR-146a can help slow or prevent growth and rupture of abdominal aortic aneurysms in people with this condition.
-
MOF’s role in weakening the aorta and stopping aneurysm growth
Scientists are studying how a molecule called MOF and inflammatory signals affect abdominal aortic aneurysms to find ways to slow or stop their enlargement.
-
Endovascular Suturing Device to Improve Endograft Fixation in Abdominal Aortic Aneurysm
A new device aims to better secure endografts during EVAR for abdominal aortic aneurysm to reduce future repairs.
-
Triglyceride-rich lipoproteins and abdominal aortic aneurysm growth
A study exploring how fats in the blood (TRLs) influence the growth of abdominal aortic aneurysms to find non-surgical ways to protect against rupture, especially in people aged 65 and older.
-
Using genetics to uncover how abdominal aortic aneurysms develop
A research team will study how genetic differences influence abdominal aortic aneurysm to help with earlier prevention and better treatment.
-
Phospholipid-based nanotherapies to treat abdominal aortic aneurysm
A new nanoparticle treatment is being developed to slow or stop the growth of abdominal aortic aneurysms in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.