Identifying biomarkers for aortic aneurysm and dissection
Official title: Diagnosis and Prognosis for Aortic Aneurysm aNd Dissection in Anzhen
Run by Beijing Institute of Heart, Lung and Blood Vessel Diseases · NCT03233087 · Data updated 2026-11-12
This study is trying to find specific markers in the blood that can help doctors diagnose and predict outcomes for people with aortic aneurysm and aortic dissection.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 1500 (estimated) |
| Sponsor | Beijing Institute of Heart, Lung and Blood Vessel Diseases Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | March 1, 2014 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2028 |
| Registry record updated | June 27, 2024 |
| Trial ID | NCT03233087 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients referred for evaluation of aortic dissection or those with suspected aortic aneurysm or dissection.
✕Probably not a fit
Patients with conditions unrelated to aortic dissection or those with significant comorbidities like active cancer or severe pulmonary diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the role of specific biomarkers in diagnosing and predicting outcomes for patients with aortic aneurysm (AA) and aortic dissection (AD). It includes a discovery phase with a matched case-control design, where patients with various outcomes are compared to healthy controls. The prognosis aspect focuses on patients with confirmed AA and AD, tracking all-cause mortality and in-hospital mortality through medical records and death certificates. The study aims to enhance understanding of these conditions and improve patient management.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and prognostic tools for patients with aortic aneurysm and dissection.
How similar studies have gone: Other studies have explored biomarkers in cardiovascular conditions, but this specific approach to aortic aneurysm and dissection is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Retrospective * All patients who were referred to the surgical service for evaluation and management of aortic dissection were included. Perspective * Patients with initial suspicion of having AAD were perspectively enrolled. Exclusion Criteria: Retrospective * Patients who received packed red blood cells, whole blood, or platelets less than 10 days before the blood sample was taken; * Patients with aortic trauma, pseudo aneurysm, history of heart failure, renal dysfunction, severe pulmonary diseases, or active cancer; * Patients who entered the hospital for checkups after surgery. Perspective * Patients in whom there is little or no suspicion of a life-threatening disease; * Patients with confirmed acute myocardial infarction,angina or pulmonary embolism * The symptoms were clearly not related to AD (e.g. pleurisy, pneumonia, acute abdominal diseases).
Where it's running
-
Beijing Anzhen Hospital
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Study coordinator: Yuan Wang, PhD
- Email: wangyuan980510@163.com
- Phone: 86-010-64456721
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.