Investigating how redox signaling affects aortic aneurysms in Marfan syndrome
Official title: Thiol redox signaling in aortic aneurysm
Funded at Boston University Medical Campus · NIH-11133210 · Data updated 2026-11-12
This study is looking at how certain chemical signals in the body might contribute to aortic aneurysms in people with Marfan syndrome, with the goal of finding new ways to prevent or treat these serious heart issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 15, 2025 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $817,498 |
| NIH project number | 1R01HL175424-01A1 |
| Project ID | NIH-11133210 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Marfan syndrome who are at risk for thoracic aortic aneurysm.
✕Less likely to help
Patients without Marfan syndrome or those who do not have aortic aneurysms may not benefit from this research.
What this research studies
This research focuses on understanding the role of thiol redox signaling in the development of aortic aneurysms, particularly in patients with Marfan syndrome. It aims to uncover the molecular mechanisms that lead to thoracic aortic aneurysm and dissection by studying the effects of oxidative stress on specific proteins involved in vascular health. By using animal models and analyzing tissue samples, the research seeks to identify potential therapeutic targets that could prevent or treat these life-threatening conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent aortic aneurysms and improve outcomes for patients with Marfan syndrome.
How similar studies have gone: Previous research has shown promising results in understanding the role of oxidative stress in vascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Seta, Francesca — Boston University Medical Campus
- Study coordinator: Seta, Francesca
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.