Understanding the causes and treatments for thoracic aortic aneurysm
Pharmacological Mechanistic Insights into Thoracic Aortic Aneurysm
This study is looking into how thoracic aortic aneurysms develop in people with Marfan syndrome, with the goal of finding new ways to treat this condition, and it involves testing different medications on animal models to see how they affect aortic health.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-11136787 on NIH RePORTER |
What this research studies
This research focuses on investigating the mechanisms behind thoracic aortic aneurysms, particularly in patients with Marfan syndrome. Led by Dr. Mary Sheppard at the University of Kentucky, the project aims to identify new therapeutic targets that could lead to better treatment options. The research involves preclinical studies using animal models to explore the effects of various pharmacological agents on aortic health. By enhancing our understanding of these mechanisms, the research seeks to pave the way for innovative therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with thoracic aortic aneurysm, particularly those with Marfan syndrome.
Not a fit: Patients with aortic aneurysms not related to genetic conditions or those without significant cardiovascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from thoracic aortic aneurysms.
How similar studies have performed: Previous research has shown promise in understanding the mechanisms of aortic aneurysms, suggesting that this approach could yield valuable insights.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Sheppard, Mary Burchett — University of Kentucky
- Study coordinator: Sheppard, Mary Burchett
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.