Understanding the causes and treatments for thoracic aortic aneurysm

Who could benefit from this research

What this research studies

This research focuses on investigating the mechanisms behind thoracic aortic aneurysms, particularly in patients with Marfan syndrome. Led by Dr. Mary Sheppard at the University of Kentucky, the project aims to identify new therapeutic targets that could lead to better treatment options. The research involves preclinical studies using animal models to explore the effects of various pharmacological agents on aortic health. By enhancing our understanding of these mechanisms, the research seeks to pave the way for innovative therapies.

Why it matters

Where this research is happening

• University of Kentucky
  Lexington, United States Active

Researchers

• Principal investigator: Sheppard, Mary Burchett — University of Kentucky
• Study coordinator: Sheppard, Mary Burchett

Related research

Other NIH-funded projects on the same topics.

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• Using AI and 3D CT scans to predict rupture risk for thoracic aortic aneurysms

  This project uses machine learning plus 3D CT scans to help identify adults with thoracic aortic aneurysms—especially smaller ones—who may be at higher risk of rupture.

  NIH research University of Miami Coral Gables · Coral Gables, United States · NIH-11260144

• Finding better warning signs for problems in the upper aorta (ascending aortic aneurysm)

  Researchers are combining mouse experiments, computer simulations, and patient scans to find sets of markers that could warn people with ascending aortic aneurysms about the risk of rapid growth, tearing, or rupture.

  NIH research Washington University · Saint Louis, United States · NIH-11117068

• Understanding how biomechanical factors affect the growth and rupture of aortic aneurysms

  This study is looking at how certain physical changes in the aorta can help us understand why some aortic aneurysms grow or tear, specifically in veterans, so we can improve how we decide when surgery is needed.

  NIH research Veterans Affairs Med Ctr San Francisco · San Francisco, United States · NIH-11073101

• Understanding how fat tissue around blood vessels affects aortic aneurysms

  This study is looking at how the fat around blood vessels might affect the development of thoracic aortic aneurysms, a serious condition, and aims to find new ways to prevent or treat it, with the help of patients who can share tissue samples or participate in related studies.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11064805

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.