Investigating a receptor's role in abdominal aortic aneurysms
Official title: The role of protease activated receptor 2 in the initiation and progression of abdominal aortic aneurysm
Funded at University of Cincinnati · NIH-11121653 · Data updated 2026-11-12
This study is looking at how a specific protein called PAR2 affects the growth and worsening of abdominal aortic aneurysms, with the goal of finding new treatment options for patients beyond just surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | May 15, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $740,338 |
| NIH project number | 1R01HL179626-01 |
| Project ID | NIH-11121653 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults, particularly those over the age of 65, who are at higher risk for developing abdominal aortic aneurysms.
✕Less likely to help
Patients under the age of 65 or those without risk factors for abdominal aortic aneurysms may not benefit from this research.
What this research studies
This research focuses on understanding how protease-activated receptor 2 (PAR2) contributes to the development and worsening of abdominal aortic aneurysms (AAA). The study aims to explore the mechanisms by which PAR2 influences vascular inflammation and the behavior of specific immune cells in the aorta. By examining the effects of PAR2 on aortic health, the research seeks to identify potential new treatment options beyond surgery for patients suffering from AAA. Patients may be involved in the research to help uncover the biological pathways that lead to this serious condition.
Why it matters
Potential benefit: If successful, this research could lead to new pharmacologic treatments for abdominal aortic aneurysms, potentially reducing the need for surgical interventions.
How similar studies have gone: While the role of PAR2 in cardiovascular diseases is being explored, this specific investigation into its role in abdominal aortic aneurysms is relatively novel and has not been extensively tested.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Owens Iii, Albert Phillip — University of Cincinnati
- Study coordinator: Owens Iii, Albert Phillip
Related research
Other NIH-funded projects on the same topics.
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How the small regulator miR-146a affects abdominal aortic aneurysm
This project aims to see if boosting a natural genetic regulator called miR-146a can help slow or prevent growth and rupture of abdominal aortic aneurysms in people with this condition.
-
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Scientists are studying how a molecule called MOF and inflammatory signals affect abdominal aortic aneurysms to find ways to slow or stop their enlargement.
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A new device aims to better secure endografts during EVAR for abdominal aortic aneurysm to reduce future repairs.
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Triglyceride-rich lipoproteins and abdominal aortic aneurysm growth
A study exploring how fats in the blood (TRLs) influence the growth of abdominal aortic aneurysms to find non-surgical ways to protect against rupture, especially in people aged 65 and older.
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Using genetics to uncover how abdominal aortic aneurysms develop
A research team will study how genetic differences influence abdominal aortic aneurysm to help with earlier prevention and better treatment.
-
Phospholipid-based nanotherapies to treat abdominal aortic aneurysm
A new nanoparticle treatment is being developed to slow or stop the growth of abdominal aortic aneurysms in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.