Triglyceride-rich lipoproteins and abdominal aortic aneurysm growth
Official title: Triglyceride-rich lipoproteins and abdominal aortic aneurysm growth and progression
Funded at University of Pennsylvania · NIH-11389655 · Data updated 2026-11-12
A study exploring how fats in the blood (TRLs) influence the growth of abdominal aortic aneurysms to find non-surgical ways to protect against rupture, especially in people aged 65 and older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 1, 2025 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $672,921 |
| NIH project number | 5R01HL181587-02 |
| Project ID | NIH-11389655 on NIH RePORTER |
Who could benefit from this research
✓Could help
Older adults with abdominal aortic aneurysm or at risk for AAA who could participate in genetic and biomarker studies or future trials.
✕Less likely to help
People without AAA or without risk factors related to TRL pathways may not benefit.
What this research studies
This project looks at whether triglyceride-rich lipoproteins contribute to AAA growth and rupture risk, with a focus on older adults. Researchers will use human genetic data and existing studies to understand how TRLs might drive the disease and test potential targets in preclinical models. The goal is to identify pathways and therapies that could slow or prevent aneurysm progression without surgery. Results could guide future clinical trials and personalized risk reduction for patients with AAA.
Why it matters
Potential benefit: If successful, the work could lead to nonsurgical treatments that slow AAA growth and reduce rupture risk in older patients.
How similar studies have gone: Previous work has linked TRL pathways to vascular disease, with some promising genetic associations supporting a role in AAA.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Damrauer, Scott Michael — University of Pennsylvania
- Study coordinator: Damrauer, Scott Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.