Phospholipid-based nanotherapies to treat abdominal aortic aneurysm
Official title: Development of phospholipid-based nanotherapeutics for treating abdominal aortic aneurysm
Funded at University of Michigan at Ann Arbor · NIH-11374518 · Data updated 2026-11-12
A new nanoparticle treatment is being developed to slow or stop the growth of abdominal aortic aneurysms in adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | July 1, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $748,657 |
| NIH project number | 5R01HL165688-04 |
| Project ID | NIH-11374518 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with abdominal aortic aneurysm or at high risk of progression may eventually benefit if this therapy advances to human trials.
✕Less likely to help
People with AAA that do not respond to anti-inflammatory strategies or who have contraindications to nanoparticle therapies may not benefit.
What this research studies
Doctors and researchers are exploring a targeted nanoparticle approach to deliver anti-inflammatory effects and support vascular cells in the abdominal aorta. The work involves preclinical models and early-stage studies to find a medical option beyond surgery for preventing aneurysm growth. If successful, this approach could reduce the need for urgent repairs and lower rupture risk for patients with AAA.
Why it matters
Potential benefit: If successful, patients with AAA could have a non-surgical option to slow progression and lower rupture risk.
How similar studies have gone: Prior studies show anti-inflammatory strategies can affect AAA in animals, but translating to humans remains challenging; this study aims to advance a novel nanotherapy.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Guo, Yanhong — University of Michigan at Ann Arbor
- Study coordinator: Guo, Yanhong
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.