Condition

Anal Cancer clinical trials and research

• 32Clinical trials
• 19NIH research projects
• 1New in 30 days
• 13Countries

Newest Anal Cancer clinical trials

All recruiting trials (32)

• Retifanlimab after chemoradiation for anal cancer

  This study tests whether retifanlimab can help people with anal squamous cell carcinoma who have completed chemoradiation and still have residual disease.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07927998

• Irreversible Electroporation for Recurrent Pelvic Tumors

  This study tests whether using irreversible electroporation (IRE) is safe and helps control recurrent pelvic tumors in adults who can’t have other local treatments.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam, North Holland · NCT07782164

• HPV DNA-guided chemoradiation with Retifanlimab for locally advanced anal cancer

  This study tests whether adjusting chemoradiation doses based on HPV ctDNA results and adding Retifanlimab after CRT can improve outcomes for adults with new, locally advanced anal cancer.

  Recruiting Phase 2 Case Comprehensive Cancer Center · Cleveland, Ohio and 1 other locations · NCT07425054

• Gynecological and sexual health after radiotherapy for anal cancer.

  See if vaginal problems and changes in sexual health are linked to radiation dose in women treated with chemoradiotherapy for anal cancer 6–36 months after treatment.

  Recruiting at 3 sites Aarhus University Hospital · Aarhus and 2 other locations · NCT07296237

• Self-sampling to improve anal lesion outcomes

  This study will test whether people at higher risk for anal cancer will use a self-collected anal swab and whether that increases follow-up cytology and high-resolution anoscopy (HRA) appointment attendance.

  Recruiting at 3 sites Medical College of Wisconsin · Chicago, Illinois and 2 other locations · NCT07192055

• Testing trastuzumab deruxtecan (T‑DxD) for HER2‑positive advanced solid tumors

  This will test whether trastuzumab deruxtecan (T‑DxD) helps adults in the US with HER2‑positive (IHC 3+) locally advanced, unresectable, or metastatic solid tumors who have had prior systemic treatment and have no satisfactory alternative options.

  Recruiting at 18 sites AstraZeneca · Birmingham, Alabama and 17 other locations · NCT07124000

• Virtual exercise program to preserve function and prevent disability during chemotherapy

  This trial tests whether supervised resistance sessions by video plus short home aerobic workouts help adults 18–64 maintain strength and stay active while receiving curative-intent chemotherapy.

  Recruiting at 29 sites Alliance for Clinical Trials in Oncology · Dublin, California and 29 other locations · NCT07059884

• Anal cancer screening for men on PrEP

  This study will test how well anal swabs and DNA methylation testing find high-grade anal lesions (HSIL) and how common those lesions are in men who have sex with men using PrEP, and whether HSIL affects quality of life.

  Recruiting at 6 sites Universitair Ziekenhuis Brussel · Bruges and 7 other locations · NCT07029152

• Screening tool for anal cancer detection using host genome methylation

  This study is trying to create a new screening tool for anal cancer that uses genetic markers to help high-risk groups, like men with HIV and women with past cancer, get tested more easily.

  Recruiting at 2 sites Assistance Publique - Hôpitaux de Paris · Paris, Île-de-France Region and 8 other locations · NCT06792604

• HPV types and disease burden of anal cancer in China

  This project will test which HPV types are found in people with anal cancer in China and describe who is affected.

  Recruiting Fudan University · Shanghai · NCT06670495

• Using SCG142 TCR-T cells to treat HPV-related cancers

  This study is testing a new type of immune cell treatment called SCG142 TCR-T cells to see if it can help people with advanced cancers related to HPV.

  Recruiting Phase 1 The Affiliated Hospital of Qingdao University · Qingdao, Shandong · NCT06544720

• HPV molecular patterns linked to high-grade anal lesions and cancer in former IPERGAY participants

  This project will test whether specific HPV molecular signatures predict high-grade anal lesions or anal cancer in people who were part of the IPERGAY HPV substudy about 10 years earlier.

  Recruiting at 3 sites ANRS, Emerging Infectious Diseases · Lyon and 2 other locations · NCT06522256

• Treatment for early-stage anal cancer using pembrolizumab and chemotherapy

  This study is testing a new combination of pembrolizumab, chemotherapy, and radiation to see if it can effectively treat early-stage anal cancer in patients who haven't received treatment before.

  Recruiting at 5 sites Phase 2 Hoosier Cancer Research Network · Indianapolis, Indiana and 4 other locations · NCT06493019

• Exploring stigma and psychological profiles in rectal and anal cancer patients

  This study looks at the feelings and challenges faced by patients with rectal and anal cancer during long-term treatment to see how these issues affect their mental health and well-being.

  Recruiting at 2 sites Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma and 1 other locations · NCT06366841

• Performance analysis of an HPV test for anal cancer screening

  This study is testing a new HPV test on anal samples to see if it can help high-risk people find anal cancer and precancerous conditions more easily.

  Recruiting European Institute of Oncology · Milan · NCT06327568

• Improving care for Black patients with gastrointestinal cancer

  This study is trying to improve cancer care for Black patients with gastrointestinal cancers by ensuring they get the right tests and treatments while helping us understand the challenges they face.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06263088

• New treatment approach for locally advanced anal cancer

  This study is testing a new treatment plan that combines chemotherapy and radiation to see if it can help people with advanced anal cancer live longer and have fewer relapses.

  Recruiting at 49 sites Phase 3 Federation Francophone de Cancerologie Digestive · Agen and 113 other locations · NCT06207981

• HRYZ-T101 injection for HPV18 positive solid tumors

  This study is testing a new injection called HRYZ-T101 to see if it can safely help people with solid tumors that are positive for HPV18.

  Recruiting Phase 1 HRYZ Biotech Co. · Shanghai, Shanghai Municipality · NCT05952947

• Understanding tissue response in anal cancer treatment

  This study looks at how anal cancer tumors interact with the body’s immune system and their surrounding environment to better understand the disease in adults who are newly diagnosed or have recurring anal cancer.

  Recruiting at 2 sites Sahlgrenska University Hospital · Gothenburg and 1 other locations · NCT05939401

• Immunotherapy using E7 TCR-T cells for HPV-related cancers

  This study is testing a new immunotherapy using E7 TCR-T cells to see if it can help people with advanced HPV-related cancers like cervical and throat cancer feel better and improve their health.

  Recruiting at 3 sites Phase 2 Rutgers, The State University of New Jersey · Bethesda, Maryland and 2 other locations · NCT05686226

• E7 T-cell therapy for advanced HPV-related cancers

  This study is testing a new treatment using specially modified immune cells to see if it can help people with advanced cancers linked to HPV feel better and live longer.

  Recruiting at 2 sites Phase 1/2 Rutgers, The State University of New Jersey · New Brunswick, New Jersey and 1 other locations · NCT05639972

• Using blood tests to improve follow-up care for anal cancer

  This study is testing if blood tests that check for tumor DNA can help doctors find out sooner if anal cancer treatment isn't working or if the cancer comes back, so patients can get better care.

  Recruiting at 3 sites Aarhus University Hospital · Herlev, Capital Region of Denmark and 12 other locations · NCT05572801

• Daily online adaptive radiotherapy for anal cancer

  This study is testing if daily online adaptive radiotherapy can help people with anal cancer experience less stomach problems compared to standard radiation treatment.

  Recruiting Herlev Hospital · Herlev · NCT05438836

• Pencil beam proton therapy for recurrent anal cancer

  This study is testing a new type of proton therapy for people with recurrent anal cancer to see if it can help control the tumor better while causing fewer side effects.

  Recruiting Phase 2 University of Aarhus · Aarhus N, Aarhus · NCT05055635

• Using virtual reality to help manage pain in GI cancer patients

  This study is testing if virtual reality can help people with GI cancer manage their severe abdominal pain better than standard treatments.

  Recruiting Cedars-Sinai Medical Center · Los Angeles, California · NCT04907643

• Finding HPV DNA in the blood of people with anal or cervical cancer.

  This study will test whether a blood test can find HPV DNA in people with HPV-related anal or cervical cancer before, during, and after radiation treatment.

  Recruiting at 2 sites University of Chicago · Chicago, Illinois and 1 other locations · NCT04857528

• Understanding quality of life and outcomes in anal cancer patients

  This study looks at how anal cancer affects patients' quality of life and health outcomes from diagnosis through treatment to see what challenges they face.

  Recruiting Sahlgrenska University Hospital · Gothenburg · NCT04792892

• Using vaginal dilators to reduce vaginal stenosis in anal cancer patients during radiotherapy

  This study is testing whether using a larger tampon for vaginal dilation during pelvic radiotherapy can help women with anal cancer avoid problems like vaginal narrowing after treatment.

  Recruiting University Hospital Heidelberg · Heidelberg · NCT04094454

• Understanding how cancer cells evade the immune system

  This study is trying to understand how cancer cells hide from the immune system by looking at blood and tumor samples from 900 patients with different types of solid tumors.

  Recruiting at 3 sites Institut Claudius Regaud · Toulouse and 2 other locations · NCT03958240

• Evaluating quality of life after chemoradiation in anal cancer patients

  This study looks at how treatment with chemoradiation affects the quality of life for people with anal cancer.

  Recruiting Ludwig-Maximilians - University of Munich · Munich, Bavaria · NCT03792854

• Screening for anal cancer in women with vulvar lesions

  This study is testing if screening for anal cancer with Pap smears can help women over 40 who have vulvar lesions catch any problems early and improve their health.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT03061435

• A resource for collecting cancer data and biospecimens

  This study is creating a resource to collect health information and samples from cancer patients and healthy individuals to help improve cancer prevention and treatment strategies.

  Recruiting at 42 sites University of Nebraska · Greenwood Village, Colorado and 41 other locations · NCT02012699

NIH-funded research (19)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Integrated approach to preventing anal cancer in HIV+ MSM through screening and treatment of HSIL

  This project tests a streamlined plan to prevent anal cancer in people living with HIV by screening for HSIL and treating it at clinics serving MSM.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11535378

• Preventing anal cancer in people living with HIV

  A topical form of HIV protease inhibitors is being tried to clear precancerous anal changes in people living with HIV.

  NIH research Wm S. Middleton Memorial Veterans Hosp · Madison, United States · NIH-11510008

• Screening strategies to find anal cancer precursors in high-risk people

  Researchers will study markers from DNA methylation and immune signals to better identify people at risk for anal cancer before it develops.

  NIH research Emory University · Atlanta, United States · NIH-11415125

• Integrated approach to preventing anal cancer in HIV-positive MSM through HSIL screening and treatment

  This project tests a proven HSIL screening-and-treatment approach to prevent anal cancer in men living with HIV, using Ghana/Nigeria-based sites to learn how to implement it broadly.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11401911

• Better screening for anal cancer in people at higher risk

  This project looks for biological and immune signals that could spot early precancerous changes in people at high risk for anal cancer.

  NIH research Emory University · Atlanta, United States · NIH-11401675

• Screen-and-treat program to prevent anal cancer in people with HIV

  This project offers regular anal screening and treatment to men who have sex with men living with HIV to lower their risk of anal cancer.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11392743

• Anal cancer screening for people with HIV using genomic methods

  A patient-centered screening approach using a genomic test to detect anal precancers in people with HIV, aiming to catch disease earlier and reduce unnecessary procedures.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11391198

• Using social media influencers to boost anal cancer prevention

  A patient-friendly plan to use trusted online voices to raise awareness and promote screening for anal cancer in high‑risk groups.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11374002

• A new probe-based imaging tool to improve anal cancer screening

  This project tries a new, non-invasive probe that images anal tissue to find precancerous and cancerous changes in people at higher risk.

  NIH research University of Arizona · Tucson, United States · NIH-11258523

• Screening for early anal precancer in women with prior cervical, vaginal, or vulvar neoplasia

  This project will see whether screening women with past cervical, vaginal, or vulvar precancers can find early anal precancers using HPV or cytology tests, including possible self-swabs.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11191472

• Screening and treatment to prevent anal cancer in people with HIV

  This program offers anal screening and treatment of high‑grade lesions to men who have sex with men living with HIV to help lower their risk of anal cancer.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11176058

• Anal cancer prevention program for people living with HIV

  This program helps people living with HIV in Georgia get education, screening follow-up, and clinic support to lower their chance of developing anal cancer.

  NIH research Emory University · Atlanta, United States · NIH-11086839

• New imaging technique for anal cancer screening

  This study is testing a new imaging technique to help doctors better spot early signs of anal cancer, making it easier for them to diagnose and treat patients who have high-grade lesions that could lead to cancer.

  NIH research University of Arizona · Tucson, United States · NIH-11036694

• Understanding how older sexual and gender minorities in Nigeria decide to engage in anal cancer prevention.

  This study is looking to understand how older LGBTQ+ individuals living with HIV in Nigeria feel about joining programs that help prevent anal cancer, so we can make these programs more appealing and accessible for them.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11020415

• Preventing anal cancer in people living with HIV

  This study is looking for better ways to prevent anal cancer in people with HIV by testing a new treatment for precancerous conditions, hoping to find options that work well and have fewer side effects.

  NIH research Wm S. Middleton Memorial Veterans Hosp · Madison, United States · NIH-10948112

• Screening women with lower genital tract cancers for anal cancer precursors

  This study is looking at how well screening for early signs of anal cancer works for women over 50 who have had certain lower genital tract issues, to see if it can help catch problems early and improve their health.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-10914069

• Preventing anal cancer in men who have sex with men living with HIV

  This study is looking to help men who have sex with men and are living with HIV by offering a program to screen and treat early signs of anal cancer, making it easier for them to get the care they need in Nigeria and the U.S.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-10907554

• Creating a decision tool to help prevent anal cancer in specific communities

  This study is creating a helpful tool to encourage men who have sex with men and transgender women to get the HPV vaccine, which can help prevent anal cancer, by using existing HIV prevention services to make it easier for them to access information and support.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-10842367

• Improving anal cancer screening for people with HIV using genetic testing

  This study is looking to improve how we check for anal cancer in people living with HIV by testing a new, gentler method that uses a special brush to collect samples, and we want to see if it works better than the usual tests.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-10785779

Related topics

Quick answers

How many Anal Cancer clinical trials are recruiting right now?

32, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (12 trials), France (4 trials), Denmark (4 trials), China (3 trials), Sweden (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 1: 2, Phase 3: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →