Understanding tissue response in anal cancer treatment
Official title: ANCABio - a Study Regarding Tumour Microenvironment and the Predictive Capability of Biopsies from Anal Cancer in Predicting Response and Outcome
Run by Sahlgrenska University Hospital · NCT05939401 · Data updated 2026-11-12
This study looks at how anal cancer tumors interact with the body’s immune system and their surrounding environment to better understand the disease in adults who are newly diagnosed or have recurring anal cancer.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | Sahlgrenska University Hospital Academic / other |
| Locations | 2 sites (Gothenburg and 1 other locations) |
| Status | Recruiting |
| Started | December 1, 2023 |
| Main results expected | December 1, 2027 |
| Study ends | December 1, 2029 |
| Registry record updated | March 18, 2025 |
| Trial ID | NCT05939401 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults with newly diagnosed or recurrent anal cancer.
✕Probably not a fit
Patients without a diagnosis of anal cancer or those who cannot undergo biopsies or blood sampling may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to enhance the understanding of tumor biology in anal cancer patients by examining the tumor microenvironment, cellular interactions between tumors and immune cells, and the gene and protein expression in tumor and surrounding tissues. Eligible participants include adults with newly diagnosed or recurrent anal cancer, who will provide biopsies and blood samples during diagnostic and follow-up examinations. The study is conducted at Sahlgrenska University Hospital, where patients will be monitored throughout their treatment process.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for anal cancer based on a better understanding of tumor biology.
How similar studies have gone: While this approach is focused on understanding tumor biology in anal cancer, similar studies in other cancer types have shown promise in improving treatment outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Newly diagnosed or recurrent anal cancer Exclusion Criteria: * No diagnosis of anal cancer, contraindication to biopsies and blood samples
Where it's running
-
Dept. of Surgery, Sahlgrenska University Hospital/Ostra
Gothenburg, Sweden Recruiting -
Sahlgrenska University Hospital
Gothenburg, Sweden Recruiting
Study contacts
- Study coordinator: Eva Angenete PI, Professor
- Email: eva.angenete@gu.se
- Phone: +46760514441
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.