Clinical trial Recruiting at 2 sites Observational Ages 18 and up

Understanding tissue response in anal cancer treatment

Official title: ANCABio - a Study Regarding Tumour Microenvironment and the Predictive Capability of Biopsies from Anal Cancer in Predicting Response and Outcome

Run by Sahlgrenska University Hospital · NCT05939401 · Data updated 2026-11-12

This study looks at how anal cancer tumors interact with the body’s immune system and their surrounding environment to better understand the disease in adults who are newly diagnosed or have recurring anal cancer.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment400 (estimated)
SponsorSahlgrenska University Hospital
Academic / other
Locations2 sites (Gothenburg and 1 other locations)
StatusRecruiting
StartedDecember 1, 2023
Main results expectedDecember 1, 2027
Study endsDecember 1, 2029
Registry record updatedMarch 18, 2025
Trial IDNCT05939401 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults with newly diagnosed or recurrent anal cancer.

Probably not a fit

Patients without a diagnosis of anal cancer or those who cannot undergo biopsies or blood sampling may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to enhance the understanding of tumor biology in anal cancer patients by examining the tumor microenvironment, cellular interactions between tumors and immune cells, and the gene and protein expression in tumor and surrounding tissues. Eligible participants include adults with newly diagnosed or recurrent anal cancer, who will provide biopsies and blood samples during diagnostic and follow-up examinations. The study is conducted at Sahlgrenska University Hospital, where patients will be monitored throughout their treatment process.

Why it matters

Potential benefit: If successful, this study could lead to improved treatment strategies for anal cancer based on a better understanding of tumor biology.

How similar studies have gone: While this approach is focused on understanding tumor biology in anal cancer, similar studies in other cancer types have shown promise in improving treatment outcomes.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Newly diagnosed or recurrent anal cancer

Exclusion Criteria:

* No diagnosis of anal cancer, contraindication to biopsies and blood samples

Where it's running

  • Dept. of Surgery, Sahlgrenska University Hospital/Ostra
    Gothenburg, Sweden
    Recruiting
  • Sahlgrenska University Hospital
    Gothenburg, Sweden
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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  • Gynecological and sexual health after radiotherapy for anal cancer.

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.