Using SCG142 TCR-T cells to treat HPV-related cancers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase 1 clinical trial evaluates the safety, tolerability, and efficacy of SCG142 TCR-T cells in patients with advanced carcinomas associated with human papillomavirus (HPV). It is a multicenter, open-label study that involves a dose escalation and expansion approach to determine the optimal dosage and assess the treatment's effects on measurable lesions. The trial aims to provide insights into the potential of T cell receptor therapy for treating various HPV-related cancers, including cervical, head and neck, anal, and vulvar cancers.

Why it matters

Who can join: the full rules

Key Inclusion Criteria:

1. Greater than or equal to 18 years of age
2. HPV associated carcinomas
3. Patients must have at least one measurable lesion defined by RECIST 1.1
4. Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

Key Exclusion Criteria:

1. Active or uncontrollable infections or other active major medical illnesses of the cardiovascular, respiratory.
2. Patients with active autoimmune diseases.
3. Patient has a known active Hepatitis B or Hepatitis C.
4. Other severe medical conditions that may limit subject\'s participation in this trial.

Where it's running

• The affiliated hosptial of qingdao university
  Qingdao, Shandong, China Recruiting

Study contacts

• Study coordinator: Hongying Lv
• Email: qdlhytiger@163.com
• Phone: +86 18661805217

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.