Clinical trial Recruiting at 1 site Observational Ages 18 and up

Daily online adaptive radiotherapy for anal cancer

Official title: ROAR-A: Re-optimization Based Online Adaptive Radiotherapy of Anal Cancer

Run by Herlev Hospital · NCT05438836 · Data updated 2026-11-12

This study is testing if daily online adaptive radiotherapy can help people with anal cancer experience less stomach problems compared to standard radiation treatment.

More Anal Cancer trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment205 (estimated)
SponsorHerlev Hospital
Academic / other
Drugs / interventionsradiation
Locations1 site (Herlev)
StatusRecruiting
StartedJanuary 1, 2022
Main results expectedJanuary 1, 2026
Study endsJanuary 1, 2031
Registry record updatedSeptember 25, 2023
Trial IDNCT05438836 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include individuals with biopsy-verified anal cancer who are eligible for curative radiotherapy.

Probably not a fit

Patients with other malignant diseases within the past five years may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of daily online adaptive radiotherapy (oART) for patients with anal cancer. It aims to determine if this approach can significantly reduce early gastrointestinal toxicity compared to traditional non-adaptive intensity modulated radiation therapy (IMRT). The study is a single-arm, prospective trial conducted at a single center, focusing on patients who are eligible for curative radiotherapy. Participants will receive daily adjustments to their treatment based on real-time imaging and anatomical changes.

Why it matters

Potential benefit: If successful, this approach could lead to reduced side effects from treatment, improving the quality of life for patients with anal cancer.

How similar studies have gone: Other studies have shown promise with adaptive radiotherapy approaches, suggesting potential benefits in reducing treatment-related toxicities.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Biopsy-verified anal cancer
* Eligible for curative intended radiotherapy
* Written and oral consent

Exclusion Criteria:

* Other malignant disease within the past 5 years (excluding basal cell carcinoma)

Where it's running

  • Oncology dept, Herlev and Gentofte Hospital
    Herlev, Denmark
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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  • HPV DNA-guided chemoradiation with Retifanlimab for locally advanced anal cancer

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  • Vaginal DHEA to improve vaginal health after pelvic radiation

    This phase II trial tests whether daily vaginal DHEA can help reduce vaginal dryness, pain, and related symptoms in menopausal women after radiation for gynecologic, anal, or rectal cancers.

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  • Gynecological and sexual health after radiotherapy for anal cancer.

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  • EVOLVE104 for advanced bladder and other squamous cell cancers

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    Recruiting at 16 sites Phase 1 EvolveImmune United, Inc · Duarte, California and 15 other locations · NCT07217171

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.