Daily online adaptive radiotherapy for anal cancer
Official title: ROAR-A: Re-optimization Based Online Adaptive Radiotherapy of Anal Cancer
Run by Herlev Hospital · NCT05438836 · Data updated 2026-11-12
This study is testing if daily online adaptive radiotherapy can help people with anal cancer experience less stomach problems compared to standard radiation treatment.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 205 (estimated) |
| Sponsor | Herlev Hospital Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Herlev) |
| Status | Recruiting |
| Started | January 1, 2022 |
| Main results expected | January 1, 2026 |
| Study ends | January 1, 2031 |
| Registry record updated | September 25, 2023 |
| Trial ID | NCT05438836 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals with biopsy-verified anal cancer who are eligible for curative radiotherapy.
✕Probably not a fit
Patients with other malignant diseases within the past five years may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effectiveness of daily online adaptive radiotherapy (oART) for patients with anal cancer. It aims to determine if this approach can significantly reduce early gastrointestinal toxicity compared to traditional non-adaptive intensity modulated radiation therapy (IMRT). The study is a single-arm, prospective trial conducted at a single center, focusing on patients who are eligible for curative radiotherapy. Participants will receive daily adjustments to their treatment based on real-time imaging and anatomical changes.
Why it matters
Potential benefit: If successful, this approach could lead to reduced side effects from treatment, improving the quality of life for patients with anal cancer.
How similar studies have gone: Other studies have shown promise with adaptive radiotherapy approaches, suggesting potential benefits in reducing treatment-related toxicities.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Biopsy-verified anal cancer * Eligible for curative intended radiotherapy * Written and oral consent Exclusion Criteria: * Other malignant disease within the past 5 years (excluding basal cell carcinoma)
Where it's running
-
Oncology dept, Herlev and Gentofte Hospital
Herlev, Denmark Recruiting
Study contacts
- Principal investigator: Eva S Serup-Hansen, MD, PhD — Herlev og Gentofte Hospital
- Study coordinator: Eva Serup-Hansen, MD, PhD
- Email: eva.serup-hansen@regionh.dk
- Phone: +4538689084
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Retifanlimab after chemoradiation for anal cancer
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This phase II trial tests whether daily vaginal DHEA can help reduce vaginal dryness, pain, and related symptoms in menopausal women after radiation for gynecologic, anal, or rectal cancers.
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Gynecological and sexual health after radiotherapy for anal cancer.
See if vaginal problems and changes in sexual health are linked to radiation dose in women treated with chemoradiotherapy for anal cancer 6–36 months after treatment.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.