Screening women with lower genital tract cancers for anal cancer precursors
Official title: The effectiveness of screening women with lower genital tract neoplasia or cancers for anal cancer precursors
Funded at Icahn School of Medicine at Mount Sinai · NIH-10914069 · Data updated 2026-11-12
This study is looking at how well screening for early signs of anal cancer works for women over 50 who have had certain lower genital tract issues, to see if it can help catch problems early and improve their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $566,629 |
| NIH project number | 5R01CA256660-04 |
| Project ID | NIH-10914069 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women aged 50 and older who have a history of lower genital tract dysplasia or cancer.
✕Less likely to help
Patients who do not have a history of lower genital tract cancers or dysplasia may not benefit from this research.
What this research studies
This research investigates the effectiveness of screening women who have had lower genital tract neoplasia or cancers for precursors to anal cancer. The study focuses on women aged 50 and older, who are at a higher risk for developing these precursors. It aims to evaluate the benefits and potential harms of screening methods, such as cytologic and HPV testing, which may even be performed by patients themselves. By identifying precancerous anal lesions early, the research seeks to improve outcomes for this vulnerable population.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and prevention of anal cancer in women at high risk.
How similar studies have gone: Previous research has shown promising results in screening for anal cancer precursors in similar high-risk populations, indicating that this approach may be effective.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Sigel, Keith Magnus — Icahn School of Medicine at Mount Sinai
- Study coordinator: Sigel, Keith Magnus
Related research
Other NIH-funded projects on the same topics.
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Integrated approach to preventing anal cancer in HIV+ MSM through screening and treatment of HSIL
This project tests a streamlined plan to prevent anal cancer in people living with HIV by screening for HSIL and treating it at clinics serving MSM.
-
Preventing anal cancer in people living with HIV
A topical form of HIV protease inhibitors is being tried to clear precancerous anal changes in people living with HIV.
-
Screening strategies to find anal cancer precursors in high-risk people
Researchers will study markers from DNA methylation and immune signals to better identify people at risk for anal cancer before it develops.
-
Integrated approach to preventing anal cancer in HIV-positive MSM through HSIL screening and treatment
This project tests a proven HSIL screening-and-treatment approach to prevent anal cancer in men living with HIV, using Ghana/Nigeria-based sites to learn how to implement it broadly.
-
Better screening for anal cancer in people at higher risk
This project looks for biological and immune signals that could spot early precancerous changes in people at high risk for anal cancer.
-
Screen-and-treat program to prevent anal cancer in people with HIV
This project offers regular anal screening and treatment to men who have sex with men living with HIV to lower their risk of anal cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.