Condition

Penile Cancer clinical trials and research

• 14Clinical trials
• 1NIH research projects
• 7Countries

Newest Penile Cancer clinical trials

All recruiting trials (14)

• EGFR-targeted therapy plus PD-1 blocker before surgery for advanced penile cancer

  This phase II trial tests whether Becotatug vedotin plus Pucotenlimab given before surgery can shrink tumors in men with advanced penile cancer and help preserve the penis when possible.

  Recruiting Phase 2 West China Hospital · Chengdu, Sichuan · NCT07518979

• Beocotatug Vedotin plus Pucotenlimab for EGFR-positive advanced penile cancer

  This trial tests whether a targeted antibody-drug conjugate plus a PD-1 inhibitor can help people with EGFR-positive advanced penile cancer who have limited or no chemotherapy options.

  Recruiting Phase 2 Fudan University · Shanghai · NCT07497919

• QL1706 with lenvatinib for previously treated penile cancer

  This trial tests whether combining QL1706 with lenvatinib can help control advanced or metastatic penile squamous cell carcinoma in people whose disease progressed after prior treatments.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guangdong · NCT07384416

• Comparing open and robot-assisted removal of groin lymph nodes for penile cancer

  This trial will test whether robot-assisted groin lymph node removal causes fewer complications and faster recovery than standard open surgery for men with penile squamous cell carcinoma who need lymphadenectomy.

  Recruiting at 8 sites University Hospital Tuebingen · Berlin and 8 other locations · NCT07378670

• MRG003 plus HX008 for EGFR-positive advanced or metastatic penile squamous cell carcinoma

  This trial tests whether combining the EGFR-targeted antibody-drug conjugate MRG003 with the PD-1 inhibitor HX008 works as a first-line treatment for men with EGFR-positive advanced or metastatic penile cancer.

  Recruiting Phase 1 West China Hospital · Chengdu, Sichuan · NCT07054307

• Treatment of rare advanced tumors with a combination of drugs

  This study is testing a new combination of drugs to see if it can help people with rare advanced tumors live longer and feel better.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT06684327

• Using Ivocizumab to treat various advanced rare tumors

  This study is testing if a new treatment called Ivocizumab can help people with different types of advanced rare tumors feel better and live longer.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT06683846

• Using SCG142 TCR-T cells to treat HPV-related cancers

  This study is testing a new type of immune cell treatment called SCG142 TCR-T cells to see if it can help people with advanced cancers related to HPV.

  Recruiting Phase 1 The Affiliated Hospital of Qingdao University · Qingdao, Shandong · NCT06544720

• Combination of chemotherapy and immunotherapy for advanced penile cancer

  This study is testing a new treatment combining chemotherapy and immunotherapy for adults with advanced penile cancer to see if it helps them respond better to therapy and manage their disease.

  Recruiting at 2 sites Phase 2 The Netherlands Cancer Institute · Leuven and 1 other locations · NCT06353906

• Immunotherapy using E7 TCR-T cells for HPV-related cancers

  This study is testing a new immunotherapy using E7 TCR-T cells to see if it can help people with advanced HPV-related cancers like cervical and throat cancer feel better and improve their health.

  Recruiting at 3 sites Phase 2 Rutgers, The State University of New Jersey · Bethesda, Maryland and 2 other locations · NCT05686226

• E7 T-cell therapy for advanced HPV-related cancers

  This study is testing a new treatment using specially modified immune cells to see if it can help people with advanced cancers linked to HPV feel better and live longer.

  Recruiting at 2 sites Phase 1/2 Rutgers, The State University of New Jersey · New Brunswick, New Jersey and 1 other locations · NCT05639972

• Using MRI to assess penile cancer before surgery

  This study is testing whether a special type of MRI can help doctors better plan surgery for men with newly diagnosed penile cancer to improve their quality of life and reduce the chance of the cancer coming back.

  Recruiting Oslo University Hospital · Oslo · NCT05447273

• Understanding lymphedema after urologic surgery

  This study looks at how often and how badly lymphedema affects people after they have surgery for urologic cancer that involves removing lymph nodes.

  Recruiting at 2 sites Vastra Gotaland Region · Gothenburg and 1 other locations · NCT05264337

• A resource for collecting cancer data and biospecimens

  This study is creating a resource to collect health information and samples from cancer patients and healthy individuals to help improve cancer prevention and treatment strategies.

  Recruiting at 42 sites University of Nebraska · Greenwood Village, Colorado and 41 other locations · NCT02012699

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how the penile cancer microbiome and p16 relate to HPV and outcomes across diverse patients

  This project will look at how the tiny microbes living in penile tumors, p16 protein levels, high-risk HPV, and clinical outcomes are connected across patients from different regions.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11302466

Related topics

Quick answers

How many Penile Cancer clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in China (7 trials), United States (3 trials), Norway (1 trial), Germany (1 trial), Sweden (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Phase 1: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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