Integrated approach to preventing anal cancer in HIV+ MSM through screening and treatment of HSIL
Official title: Integrated Model for the Prevention of Anal Cancer using screen and Treat for HSIL (IMPACT)
Funded at University of Maryland Baltimore · NIH-11535378 · Data updated 2026-11-12
This project tests a streamlined plan to prevent anal cancer in people living with HIV by screening for HSIL and treating it at clinics serving MSM.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 15, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $148,197 |
| NIH project number | 3U01CA275053-05S1 |
| Project ID | NIH-11535378 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults living with HIV who are MSM and at risk for HSIL/anal cancer, able to receive HSIL screening and treatment.
✕Less likely to help
People not receiving HSIL screening or treatment or those who do not have access to participating clinics may not benefit.
What this research studies
If approved, the project will scale up HSIL screening and treatment within HIV care settings, using existing clinic networks to speed adoption. It builds on a US randomized trial showing HSIL treatment reduces cancer risk and will extend these methods through an MSM-focused Nigerian clinic to test real-world implementation. The team will identify barriers to use and fidelity, and implement strategies to overcome them in diverse clinical environments. Participants are adults living with HIV who are at risk for anal cancer, with a focus on the MSM community, to determine how best to integrate HSIL care into routine HIV services.
Why it matters
Potential benefit: If successful, this work could reduce anal cancer risk among HIV-positive MSM by making HSIL screening and treatment a standard part of care.
How similar studies have gone: Previous trials showed HSIL treatment is effective; this grant focuses on real-world adoption and implementation.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Nowak, Rebecca G. — University of Maryland Baltimore
- Study coordinator: Nowak, Rebecca G.
Related research
Other NIH-funded projects on the same topics.
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Preventing anal cancer in people living with HIV
A topical form of HIV protease inhibitors is being tried to clear precancerous anal changes in people living with HIV.
-
Screening strategies to find anal cancer precursors in high-risk people
Researchers will study markers from DNA methylation and immune signals to better identify people at risk for anal cancer before it develops.
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Integrated approach to preventing anal cancer in HIV-positive MSM through HSIL screening and treatment
This project tests a proven HSIL screening-and-treatment approach to prevent anal cancer in men living with HIV, using Ghana/Nigeria-based sites to learn how to implement it broadly.
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Better screening for anal cancer in people at higher risk
This project looks for biological and immune signals that could spot early precancerous changes in people at high risk for anal cancer.
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Screen-and-treat program to prevent anal cancer in people with HIV
This project offers regular anal screening and treatment to men who have sex with men living with HIV to lower their risk of anal cancer.
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Anal cancer screening for people with HIV using genomic methods
A patient-centered screening approach using a genomic test to detect anal precancers in people with HIV, aiming to catch disease earlier and reduce unnecessary procedures.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.